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Proline rich-oligopeptides: Diverse mechanisms for antihypertensive action
(Elsevier B.V., 2013-10-01)
Bradykinin-potentiating peptides from Bothrops jararaca (Bj) discovered in the early 1960s, were the first natural inhibitors of the angiotensin-converting enzyme (ACE). These peptides belong to a large family of snake ...
New proline-rich oligopeptides from the venom of African adders: Insights into the hypotensive effect of the venoms
(Elsevier B.V., 2015-06-01)
Background: the snakes from the Bitis genus are some of the most medically important venomous snakes in sub Saharan Africa, however little is known about the composition and effects of these snake venom peptides. Considering ...
Bj-PRO-5a, a natural angiotensin-converting enzyme inhibitor, promotes vasodilatation mediated by both bradykinin B(2) and M1 muscarinic acetylcholine receptors
(PERGAMON-ELSEVIER SCIENCE LTD, 2011)
Bradykinin-potentiating peptides (BPPs) or proline-rich oligopeptides (PROs) isolated from the venom glands of Bothrops jararaca (Bj) were the first natural inhibitors of the angiotensin-converting enzyme (ACE) described. ...
The Central Nervous System as Target for Antihypertensive Actions of a Proline-Rich Peptide from Bothrops jararaca Venom
(WILEY-LISS, 2010)
Pyroglutamyl proline-rich oligopeptides, present in the venom of the pit viper Bothrops jararaca (Bj-PROs), are the first described naturally occurring inhibitors of the angiotensin I-converting enzyme (ACE). The inhibition ...
The Central Nervous System as Target for Antihypertensive Actions of a Proline-Rich Peptide from Bothrops jararaca Venom
(Wiley-Blackwell, 2010-03-01)
Pyroglutamyl proline-rich oligopeptides, present in the venom of the pit viper Bothrops jararaca (Bj-PROs), are the first described naturally occurring inhibitors of the angiotensin I-converting enzyme (ACE). the inhibition ...
Brain nitric oxide production by a proline-rich decapeptide from Bothrops jararaca venom improves baroreflex sensitivity of spontaneously hypertensive rats
(NATURE PUBLISHING GROUP, 2010)
Baroreflex sensitivity is disturbed in many people with cardiovascular diseases such as hypertension. Brain deficiency of nitric oxide (NO), which is synthesized by NO synthase (NOS) in the citrulline-NO cycle (with ...
A novel physiological property of snake bradykinin-potentiating peptides-Reversion of MK-801 inhibition of nicotinic acetylcholine receptors
(ELSEVIER SCIENCE INC, 2008)
The first naturally occurring angiotensin-converting enzyme (ACE) inhibitors described are pyroglutamyl proline-rich oligopeptides, found in the venom of the viper Bothrops jararaca, and named as bradykinin-potentiating ...
Avaliação dos efeitos dos peptídeos ricos em prolina do veneno da serpente Bothrops jararaca Bj-PRO-7a e Bj-PRO-10c na revascularização de membros posteriores isquêmicos
(Universidade Federal de Minas GeraisUFMG, 2013-04-03)
Therapeutic angiogenesis has been proposed as an alternative for treating ischemic diseases. Angiotensin converting enzyme inhibitors (ACEi) beyond its antihypertensive effects are also able of enhacing ischemia-induced ...