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Specific insulin and proinsulin secretion in glucokinase-deficient individuals
(Associação Brasileira de Divulgação Científica, 1999-04-01)
Glucokinase (GCK) is an enzyme that regulates insulin secretion, keeping glucose levels within a narrow range. Mutations in the glucokinase gene cause a rare form of diabetes called maturity-onset diabetes of the young ...
Hypothyroidism decreases proinsulin gene expression and the attachment of its mRNA and eEF1A protein to the actin cytoskeleton of INS-1E cells
(Associação Brasileira de Divulgação Científica, 2011)
The actions of thyroid hormone (TH) on pancreatic beta cells have not been thoroughly explored, with current knowledge being limited to the modulation of insulin secretion in response to glucose, and beta cell viability ...
A specific and highly sensitive time-resolved fluoroimmunoassay for human proinsulin
(Assoc Bras Divulg Cientifica, 1996-02-01)
We describe a time-resolved fluoroimmunoaaaay specific for human Key words proinsulin using a combination of two high-affinity monoclonal antibodies, one against insulin and the other specific for intact proinsulin and for ...
Recombinant human proinsulin from transgenic corn endosperm: solvent screening and extraction studies
(Brazilian Society of Chemical Engineering, 2007)
Specific insulin and proinsulin in normal glucose tolerant first-degree relatives of NIDDM patients
(Associação Brasileira de Divulgação Científica, 1999-01-01)
In order to identify early abnormalities in non-insulin-dependent diabetes mellitus (NIDDM) we determined insulin (using an assay that does not cross-react with proinsulin) and proinsulin concentrations. The proinsulin/insulin ...
Proinsulin serum concentrations in women with polycystic ovary syndrome: a marker of beta-cell dysfunction?
(OXFORD UNIV PRESS, 2003-12)
BACKGROUND: The aim of this study was to establish the effect of polycystic ovary syndrome (PCOS) adjusted for adiposity on proinsulin concentrations. METHODS: Ninety-one women with PCOS and 72 normal cycling (NC) women ...
Low levels of sex hormone-binding globulin and hyperproinsulinemia as markers of increased pancreatic ß-cell demand in men
(Associação Brasileira de Divulgação Científica, 1998-12-01)
Low levels of sex hormone-binding globulin (SHBG) are considered to be an indirect index of hyperinsulinemia, predicting the later onset of diabetes mellitus type 2. In the insulin resistance state and in the presence of ...
Interaction of histidine-tagged human proinsulin with immobilized nickel ion: Effect of chelating ligand and thermodynamics analysis
(Elsevier Science BvAmsterdamHolanda, 2010)