Buscar
Mostrando ítems 1-10 de 37
Loss of TrkB signaling due to status epilepticus induces a proBDNF-dependent cell death
(Frontiers Research Foundation, 2019-01-08)
Neurotrophins (NTs) are secretory proteins that bind to target receptors and influence many cellular functions, such as cell survival and cell death in neurons. The mammalian NT brain-derived neurotrophic factor (matBDNF) ...
proBDNF and p75NTR control excitability and persistent firing of cortical pyramidal neurons
(Society for Neuroscience, 2015-07)
Persistent firing of entorhinal cortex (EC) pyramidal neurons is a key component of working and spatial memory. We report here that a pro-brain-derived neurotrophic factor (proBDNF)-dependent p75NTR signaling pathway plays ...
Mechanisms That Modulate and Diversify BDNF Functions: Implications for Hippocampal Synaptic Plasticity
(Frontiers Media S.A., 2019-01)
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that has pleiotropic effects on neuronal morphology and synaptic plasticity that underlie hippocampal circuit development and cognition. Recent advances established ...
Growth factors and hormones pro-peptides: the unexpected adventures of the BDNF prodomain
(Wiley Blackwell Publishing, Inc, 2017-05)
Most growth factors and hormones are synthesized as pre-pro-proteins which are processed to the biologically active mature protein. The pre- and prodomains are cleaved from the precursor protein in the secretory pathway ...
Efeito de uma sessão de exercício aeróbico nos níveis séricos de fator neurotrófico derivado do cérebro (BDNF) e de seu precursor (proBDNF) em indivíduos após Acidente Vascular Cerebral (AVC) na fase crônica
(Universidade Federal de Minas GeraisUFMG, 2014-08-01)
The brain-derived neurotrophic factor (BDNF) is an important element in the neuronal plasticity process and its levels can be modified after aerobic exercise. Studies have investigated the association between serum levels ...
CLASSICAL AVERSIVE CONDITIONING INDUCES INCREASED EXPRESSION OF MATURE-BDNF IN THE HIPPOCAMPUS AND AMYGDALA OF PIGEONS
(Pergamon-elsevier Science LtdOxfordInglaterra, 2013)
Efeito do exercício aeróbico agudo nos níveis séricos de fator neurotróficoderivado do cérebro (BDNF) e de seu precursor (proBDNF), interleucina 6 (IL-6)e receptores solúveis de fator de necrose tumoral (sTNFR1 e sTNFR2) em indivíduos com doença de Parkinson
(Universidade Federal de Minas GeraisUFMG, 2015-08-25)
Changes in the levels of neurotrophic factors and inflammatory mediators have been associated to beneficial effects caused by physical exercise, acute or chronic. Whereas Parkinson's disease (PD) is a neurological, chronic ...
THE ANTIDEPRESSIVE EFFECT OF THE PHYSICAL EXERCISE CORRELATES WITH INCREASED LEVELS OF MATURE BDNF, AND proBDNF PROTEOLYTIC CLEAVAGE-RELATED GENES, p11 AND tPA
(Pergamon-elsevier Science LtdOxfordInglaterra, 2011)