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Microglial Priming in Infections and Its Risk to Neurodegenerative Diseases
(Frontiers Media, 2022)
Hepcidin attenuates amyloid beta-induced inflammatory and pro-oxidant responses in astrocytes and microglia
(Wiley, 2017)
Alzheimer's disease (AD) is characterized by extracellular senile plaques, intracellular neurofibrillary tangles, and neuronal death. Aggregated amyloid-beta (A beta) induces inflammation and oxidative stress, which have ...
Hepcidin attenuates amyloid beta-induced inflammatory and pro-oxidant responses in astrocytes and microglia
(2017)
Alzheimer's disease (AD) is characterized by extracellular senile plaques, intracellular neurofibrillary tangles, and neuronal death. Aggregated amyloid-β (Aβ) induces inflammation and oxidative stress, which have pivotal ...
O efeito do exercício físico na atividade da micróglia em doenças neurodegenerativas: uma revisão integrativa de literatura
(Universidade Federal de Santa MariaBrasilEducação FísicaUFSMPrograma de Pós-Graduação em Ciência do Movimento e ReabilitaçãoCentro de Educação Física e Desportos, 2023-03-06)
Neuroinflammation, known to be an inflammatory response that occurs in the central nervous system (CNS), is one of the main factors responsible for several neurodegenerative pathologies, we highlight Alzheimer's Disease ...
The neurotoxic effect of cuprizone on oligodendrocytes depends on the presence of pro-inflammatory cytokines secreted by microglia
(Springer/Plenum Publishers, 2007-12)
In order to further characterize the still unknown mechanism of cuprizone-induced demyelination, we investigated its effect on rat primary oligodendroglial cell cultures. Cell viability was not significantly affected by ...
Mineralocorticoid receptor associates with pro-inflammatory bias in the hippocampus of spontaneously hypertensive rats
(Wiley, 2017-07)
Damage observed in the hippocampus of the adult spontaneously hypertensive rat (SHR) resembles the neuropathology of mineralocorticoid-induced hypertension, supporting a similar endocrine dysfunction in both entities. In ...
Microglia and astrocyte activation in the frontal cortex of rats with experimental autoimmune encephalomyelitis
(Pergamon-Elsevier Science Ltd, 2016-02)
Experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for the human disease multiple sclerosis (MS), a demyelinating and neurodegenerative pathology of the central nervous system. Both diseases share ...
Progesterone administration reduces the number of hypertrophic microglia/macrophages and modulates the expression profile of M1/M2 markers and inflammasome components after acute experimental spinal cord injury
(Fondazione Cavalieri Ottolenghi, 2021)
Neuroinflammation is a hallmark of central nervous system pathologies, including spinal cord injury (SCI). In particular, the acute activation of macrophages and resident microglia are critically implicated in the detrimental ...
Dopamine receptor D3 signalling in astrocytes promotes neuroinflammation
(Facultad de Medicina y Ciencia, 2019)
Background Neuroinflammation constitutes a pathogenic process leading to neurodegeneration in several disorders, including Alzheimer's disease, Parkinson's disease (PD) and sepsis. Despite microglial cells being the central ...
Secretoma de células madre mesenquimáticas humanas como tratamiento antioxidante y antinflamatorio de microglías de rata expuestas a opioides
(Universidad de Chile, 2021)
El consumo no controlado de opioides se ha convertido en un grave problema de salud pública
en el mundo, debido a la dependencia física que estos generan. Las tasas de adicción,
recaída al consumo y muertes por sobredosis ...