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Astrocytes as the main players in primary degenerative disorders of the human central nervous system
(Frontiers Media S.A., 2016)
Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress
(Frontiers Research Foundation, 2014-02)
Amyotrophic lateral sclerosis (ALS) is a fatal paralytic disorder caused by dysfunction
and degeneration of motor neurons. Multiple disease-causing mutations, including in the
genes for SOD1 and TDP-43, have been identified ...
Astrócitos imunorreativos à proteína glial fibrilar ácida (GFAP) em sistema nervoso central de equinos normais e de equinos com leucoencefalomalácia
(Colégio Brasileiro de Patologia Animal - CBPA, 1999-07-01)
A proteína glial fibrilar ácida (GFAP), subunidade dos filamentos intermediários do citoesqueleto celular, está presente no citoplasma de astrócitos. Técnicas imunohistoquímicas com anticorpos primários anti-GFAP são ...
Astrócitos imunorreativos à proteína glial fibrilar ácida (GFAP) em sistema nervoso central de equinos normais e de equinos com leucoencefalomalácia
(Colégio Brasileiro de Patologia Animal - CBPA, 1999-07-01)
A proteína glial fibrilar ácida (GFAP), subunidade dos filamentos intermediários do citoesqueleto celular, está presente no citoplasma de astrócitos. Técnicas imunohistoquímicas com anticorpos primários anti-GFAP são ...
Astrócitos imunorreativos à proteína glial fibrilar ácida (GFAP) em sistema nervoso central de equinos normais e de equinos com leucoencefalomalácia
(Colégio Brasileiro de Patologia Animal - CBPA, 2014)
Clostridium perfringens epsilon toxin induces permanent neuronal degeneration and behavioral changes
(Pergamon-Elsevier Science Ltd, 2017-05)
Clostridium perfringens epsilon toxin (ETX), the most potent toxin produced by this bacteria, plays a key role in the pathogenesis of enterotoxaemia in ruminants, causing brain edema and encephalomalacia. Studies of animals ...
Avaliação da teneurina-2 em astrócitos reativos no modelo experimental de epilepsia induzida com cloreto de lítio-cloridrato de pilocarpina em ratos adultos. Análises imunoistoquímica, histoquímica e de expressão gênica
(Universidade Estadual Paulista (Unesp), 2019-12-02)
As teneurinas (Tens) são proteínas transmembrana do tipo II, constituídas de quatro membros homólogos (Ten-1-4). Estas proteínas são expressas principalmente durante a neurogênese do sistema nervoso central (SNC) e estão ...
Clostridium perfringens epsilon toxin induces permanent neuronal degeneration and behavioral changes
(2017-05)
Clostridium perfringens epsilon toxin (ETX), the most potent toxin produced by this bacteria, plays a key role in the pathogenesis of enterotoxaemia in ruminants, causing brain edema and encephalomalacia.
Studies of animals ...
Long-term effects of the glucocorticoid receptor modulator CORT113176 in murine motoneuron degeneration
(Elsevier Science, 2020-01)
The Wobbler mouse spinal cord shows vacuolated motoneurons, glial reaction, inflammation and abnormal glutamatergic parameters. Wobblers also show deficits of motor performance. These conditions resemble amyotrophic lateral ...
Melanocortin 4 receptor activation protects striatal neurons and glial cells from 3-nitropropionic acid toxicity
(Academic Press Inc Elsevier Science, 2019-01)
α-Melanocyte stimulating hormone (α-MSH) is a melanocortin which exerts potent anti-inflammatory and anti-apoptotic effects. Melanocortin 4 receptors (MC4R) are abundantly expressed in the brain and we previously demonstrated ...