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Preterm birth impairs postnatal lung development in the neonatal rabbit model
(2020)
Background: Bronchopulmonary dysplasia continues to cause important respiratory morbidity throughout life, and new therapies are needed. The common denominator of all BPD cases is preterm birth, however most preclinical ...
Local pulmonary drug delivery in the preterm rabbit: feasibility and efficacy of daily intratracheal injections
(American Physiological Society, 2019-04)
Recent clinical trials in newborns have successfully used surfactant as a drug carrier for an active compound, to minimize systemic exposure. To investigate the translational potential of surfactant-compound mixtures and ...
Progressive Vascular Functional and Structural Damage in a Bronchopulmonary Dysplasia Model in Preterm Rabbits Exposed to Hyperoxia
(2016)
Bronchopulmonary dysplasia (BPD) is caused by preterm neonatal lung injury and results in oxygen dependency and pulmonary hypertension. Current clinical management fails to reduce the incidence of BPD, which calls for novel ...
SP-A ADDITION TO EXOGENOUS SURFACTANT FOR RESPIRATORY DISTRESS SYNDROME IN PRETERM RABBITS
(Springer, 2011-11-01)
Simvastatin attenuates lung functional and vascular effects of hyperoxia in preterm rabbits
(Nature Pub Group, 2020-06)
Background: Bronchopulmonary dysplasia (BPD) remains a frequent complication following preterm birth, affecting respiratory health throughout life. Transcriptome analysis in a preterm rabbit model for BPD revealed dysregulation ...
Lung morphometry, collagen and elastin content: changes after hyperoxic exposure in preterm rabbits
(Faculdade de Medicina / USP, 2009)
INTRODUCTION: Elastic and collagen fiber deposition increases throughout normal lung development, and this fiber network significantly changes when development of the lung is disturbed. In preterm rats and lambs, prolonged ...
Caffeine prevents hyperoxia-induced functional and structural lung damage in preterm rabbits
(Karger, 2016)
BACKGROUND:
Caffeine is a commonly used drug for apnea of prematurity. It may, however, also have a beneficial effect on bronchopulmonary dysplasia (BPD), which is the most common complication of extreme preterm ...
Caffeine prevents hyperoxia-induced functional and structural lung damage in preterm rabbits
(Karger, 2016)
BACKGROUND:
Caffeine is a commonly used drug for apnea of prematurity. It may, however, also have a beneficial effect on bronchopulmonary dysplasia (BPD), which is the most common complication of extreme preterm ...