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Humanized mouse models of rheumatoid arthritis for studies on immunopathogenesis and preclinical testing of cell-based therapies
(Frontiers Media S.A., 2019)
Copyright © 2019 Schinnerling, Rosas, Soto, Thomas and Aguillón. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other ...
Preclinical evaluation of the efficacy of antivenoms for snakebite envenoming: State-of-the-art and challenges ahead
(2017-05)
Animal-derived antivenoms constitute the mainstay in the therapy of snakebite envenoming. The efficacy of antivenoms to neutralize toxicity of medically-relevant snake venoms has to be demonstrated through meticulous ...
Preclinical evaluation of the efficacy of antivenoms for snakebite envenoming: State-of-the-art and challenges ahead
(2017-05)
Animal-derived antivenoms constitute the mainstay in the therapy of snakebite envenoming. The efficacy of antivenoms to neutralize toxicity of medically-relevant snake venoms has to be demonstrated through meticulous ...
Humanized Mouse Models of Rheumatoid Arthritis for Studies on Immunopathogenesis and Preclinical Testing of Cell-Based Therapies
(Facultad de Medicina y Ciencia, 2019)
Rodent models of rheumatoid arthritis (RA) have been used over decades to study the immunopathogenesis of the disease and to explore intervention strategies. Nevertheless, mouse models of RA reach their limit when it comes ...
Novel snakebite therapeutics must be tested in appropriate rescue models to robustly assess their preclinical efficacy
(2020)
In the field of antivenom research, development, and manufacture, it is often advised to follow the World Health Organization’s (WHO) guidelines for the production, control, and regulation of snake antivenom immunoglobulins, ...
Protocol for a systematic review and meta-analysis of data from preclinical studies employing the forced swimming test: an update.
(BMJ Publishing Group, 2019-02)
Objective Forced swimming test (FST) in rodents is a widely used behavioural test for screening antidepressants in preclinical research. Translational value of preclinical studies may be improved by appraisal of the quality ...
The utility of rhesus monkey (Macaca mulatta) and other non-human primate models for preclinical testing of Leishmania candidate vaccines - a review
(Fundação Oswaldo Cruz. Instituto Oswaldo Cruz, 2008)
Preclinical dental training: Association between difficulty in performing restorative procedures and the adoption of ergonomic posture
(2019-08-01)
Objective: The aim of this study was to determine any correlations between difficulty in performing restorative procedures and the adoption of ergonomic posture by dental students in a preclinical course. Methods: The ...