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Fibroblast contributes for osteoblastic phenotype in a MAPK-ERK and sonic hedgehog signaling-independent manner
(2017-12-01)
We hypothesized that a crosstalk between osteoblast and fibroblast (FB) exists, which contributes to bone as a dynamic tissue. Cell-free supernatants were harvested from fibroblast cultures and later subject pre-osteoblasts ...
Titanium-enriched medium drives low profile of ECM remodeling as a pre-requisite to pre-osteoblast viability and proliferative phenotype
(2018-12-01)
Titanium is widely used for biomedical applications, but little information is being delivered regarding the cellular/molecular mechanisms explaining their efficacy, mainly considering the effects of the Ti-released trace ...
Nano hydroxyapatite-blasted titanium surface affects pre-osteoblast morphology by modulating critical intracellular pathways
(2017-08-01)
Although, intracellular signaling pathways are proposed to predict the quality of cell-surface relationship, this study addressed pre-osteoblast behavior in response to nano hydroxyapatite (HA)-blasted titanium (Ti) surface ...
Titanium-released from dental implant enhances pre-osteoblast adhesion by ROS modulating crucial intracellular pathways
(2017-11-01)
It is important to understand the cellular and molecular events that occur at the cell–material interface of implants used for bone repair. The mechanisms involved in the initial stages of osteoblast interactions with the ...
Fibroblast and pre-osteoblast cell adhesive behavior on titanium alloy coated with diamond film
(2017-01-01)
It is well known that titanium alloys have mechanical strengths comparable to steels, as well as high corrosion resistance. Also, they have the advantage of promoting osseointegration, when used in medical and dental ...
Nano hydroxyapatite-blasted titanium surface creates a biointerface able to govern Src-dependent osteoblast metabolism as prerequisite to ECM remodeling
(2018-03-01)
Over the last several years, we have focused on the importance of intracellular signaling pathways in dynamically governing the biointerface between pre-osteoblast and surface of biomaterial. Thus, this study investigates ...
TNF alpha contributes for attenuating both Y(397)FAK and Y(416)Src phosphorylations in osteoblasts
(Wiley-Blackwell, 2014-11-01)
ObjectiveOur poor understanding of how inflammatory mediators can affect osteoblast behavior led us to investigate the tumor necrosis factor (TNF)-induced focal adhesion kinase (FAK) and Src phosphorylation.Material and ...
Zirconia stimulates ECM-remodeling as a prerequisite to pre-osteoblast adhesion/proliferation by possible interference with cellular anchorage
(2018-04-01)
The biological response to zirconia (ZrO2) is not completely understood, which prompted us to address its effect on pre-osteoblastic cells in both direct and indirect manner. Our results showed that zirconia triggers ...