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Solid dispersions with hydrogenated castor oil increase solubility, dissolution rate and intestinal absorption of praziquantel
(2010-01-01)
The solubility behavior of drugs remains one of the most challenging aspects in formulation development. Solid Dispersion (SD) has tremendous potential for improving drug solubility. Although praziquantel (PZQ) is the first ...
Solid dispersions with hydrogenated castor oil increase solubility, dissolution rate and intestinal absorption of praziquantel
(Universidade de São Paulo, Faculdade de Ciências Farmacêuticas, 2010)
The solubility behavior of drugs remains one of the most challenging aspects in formulation development. Solid Dispersion (SD) has tremendous potential for improving drug solubility. Although praziquantel (PZQ) is the first ...
Solid dispersions with hydrogenated castor oil increase solubility, dissolution rate and intestinal absorption of praziquantel
(Universidade de São Paulo (USP), Conjunto Quimicas, 2014)
Effectiveness of hyperbaric oxygen for experimental treatment of schistosomiasis mansoni using praziquantel-free and encapsulated into liposomes: Assay in adult worms and oviposition
(Elsevier B. V., 2015)
The treatment of schistosomiasis depends on a single drug: praziquantel (PZQ). However, this treatment presents limitations such as low and/or erratic bioavailability that can contribute to cases of tolerance. Improvements ...
LC Evaluation of Intestinal Transport of Praziquantel
(Vieweg, 2009-06-01)
Praziquantel (PZQ) is a highly lipophilic drug with low aqueous solubility. Despite this, it is well absorbed from the gastrointestinal tract. In this study, a simple LC method was developed and validated, in order to ...
Liposomal-praziquantel: Efficacy against Schistosoma mansoni in a preclinical assay
(2013-10-01)
Currently, schistosomiasis mansoni is treated clinically with praziquantel (PZQ). Nevertheless, cases of tolerance and resistance to this drug have been reported, creating the need to develop new drugs or to improve existing ...
Development and physicochemical characterization of solid dispersions containing praziquantel for the treatment of schistosomiasis
(2017-02-01)
Praziquantel (PZQ) is an anthelminthic agent active against parasitic flatworms of the Schistosoma type and the most important drug for the treatment and morbidity control of schistosomiasis. In this study, a high-performance ...
Liposomal-praziquantel: Efficacy against Schistosoma mansoni in a preclinical assay
(2013-10-01)
Currently, schistosomiasis mansoni is treated clinically with praziquantel (PZQ). Nevertheless, cases of tolerance and resistance to this drug have been reported, creating the need to develop new drugs or to improve existing ...
Preparação de dispersões sólidas de praziquantel com polivinilpirrolidona pelo processo do fluido supercrítico
(Universidade Estadual Paulista (Unesp), 2009-08-13)
Este estudo avalia as propriedades físico-químicas do praziquantel (PZQ) em dispersões sólidas (DS) preparadas através de tecnologia de fluido supercrítico (FSC). As DS de PZQ com polivinilpirrolidona K30 (PZQ: PVP K30) ...