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Estudo dos ligantes da proteína prion celular com ênfase em estress inducible protein 1: modificação pós-traducional, tráfego e sinalização
(Universidade Federal de Minas GeraisUFMG, 2010-09-24)
The cellular prion protein (PrPC) is a dynamic platform for the assembly of signalling modules at the cell surface. One of the best described ligand of PrPC is the co-chaperonine Stress Inducible Protein1 or STI1. This ...
Engagement of cellular prion protein with the co-chaperone Hsp70/90 organizing protein regulates the proliferation of glioblastoma stem-like cells
(BioMed Central, 2017)
Abstract
Background
Glioblastoma (GBM), a highly aggressive brain tumor, contains a subpopulation of glioblastoma stem-like cells (GSCs) that play roles in tumor maintenance, ...
Internalização e tráfego de PrPs
(Universidade Federal de Minas GeraisUFMG, 2005-03-29)
Cellular prion protein (PrPsen ou PrPc) is expressed in a wide variety of cells, specialy neurons. This protein is rich in alpha helix structures, but it can assume an alternative conformational isoform known as PrPres (or ...
Prion protein NMR structures of chickens, turtles, and frogs
(NATL ACAD SCIENCES, 2005-01-18)
The NMR structures of the recombinant prion proteins from chicken (Gallus gallus; chPrP), the red-eared slider turtle (Trachemys scripta; tPrP), and the African clawed frog (Xenopus laevis; xlPrP) are presented. The amino ...
Cellular prion protein interaction with vitronectin supports axonal growth and is compensated by integrins
(Company of Biologists Ltd, 2007-06-01)
The physiological functions of the cellular prion protein, PrPC, as a cell surface pleiotropic receptor are under debate. We report that PrPC interacts with vitronectin but not with fibronectin or collagen. the binding ...
Increased sensitivity to seizures in mice lacking cellular prion protein
(Lippincott Williams & Wilkins, 1999-12-01)
Purpose: the physiologic role of the cellular prion protein (PrPc) is unknown. Mice devoid of PrPc develop normally and show only minor deficits. However, electrophysiologic and histologic alterations found in these mice ...
The functional links between prion protein and copper
(Sociedad de Biología de Chile, 2006)
Neuroprotective alpha-cleavage of the human prion protein significantly impacts Cu(II) coordination at its His111 site
(Royal Society of Chemistry, 2018-01)
The cellular prion protein (PrPC) is a copper binding protein that undergoes post-translational modifications, such as endoproteolytic alpha cleavage, which occurs in the vicinity of the His111 Cu binding site. Alpha ...
Cellular prion protein binds laminin and mediates neuritogenesis
(Elsevier B.V., 2000-03-10)
Laminin (LN) plays a major role in neuronal differentiation, migration and survival. Here, we show that the cellular prion protein (PrPc) is a saturable, specific, high-affinity receptor for LN. the PrPc-LN interaction is ...