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PPAR beta/delta and PPAR gamma maintain undifferentiated phenotypes of mouse adult neural precursor cells from the subventricular zone

Bernal, Carolina; Araya, Claudia; Palma Alvarado, Verónica; Bronfman, Miguel (Frontiers Research Foundation, 2015)

The subventricular zone (SVZ) is one of the main niches of neural stem cells in the adult mammalian brain. Stem and precursor cells in this region are the source for neurogenesis and oligodendrogesis, mainly in the olfactory ...

Charmm Force Field Parameterization Of Peroxisome Proliferator-activated Receptor Gamma Ligands

Mottin; Melina; Souza; Paulo C. T.; Ricci; Clarisse G.; Skaf; Munir S. (MDPI AGBasel, 2017)

Structural requirement for PPAR gamma binding revealed by a meta analysis of holo-crystal structures

NASCIMENTO, Alessandro S. (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2010)

PPAR gamma is a ligand regulated transcriptional factor that modulates the transcription of several genes involved in fat and sugar metabolism. Due to its easy bacterial expression and crystallization, several crystal ...

Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis

Fuenzalida, Karen; Quintanilla, Rodrigo; Ramos, Patricio; Piderit, Daniela; Fuentealba, Rodrigo A.; Martinez, Gabriela; Inestrosa, Nibaldo C.; Bronfman, Miguel (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2007)

Peroxisome proliferator-activated receptor gamma(PPAR gamma) has been proposed as a therapeutic target for neurodegenerative diseases because of its anti-inflammatory action in glial cells. However, PPAR gamma agonists ...

Medium Chain Fatty Acids Are Selective Peroxisome Proliferator Activated Receptor (PPAR) gamma Activators and Pan-PPAR Partial Agonists

Universidade de São Paulo (USP); Houston Methodist Hospital; Universidade Estadual Paulista (Unesp); Universidade de Brasília (UnB); Universidade Estadual de Campinas (UNICAMP) (Public Library Science, 2012-05-23)

Thiazolidinediones (TZDs) act through peroxisome proliferator activated receptor (PPAR) gamma to increase insulin sensitivity in type 2 diabetes (T2DM), but deleterious effects of these ligands mean that selective modulators ...

New PPAR alpha/gamma/delta Optimal Activator Rationally Designed by Computational Methods

Universidade Estadual Paulista (Unesp); Universidade de São Paulo (USP); Univ Fed Amapa (Soc Brasileira Quimica, 2016-09-01)

The peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor that acts as a transcription factor, regulating glucose, lipid and inflammation signaling and it is exploited in type 2 diabetes ...

Molecular Recognition Of Ppar Gamma By Kinase Cdk5/p25: Insights From A Combination Of Protein-protein Docking And Adaptive Biasing Force Simulations

Mottin; Melina; Souza; Paulo C. T.; Skaf; Munir S. (AMER CHEMICAL SOCWASHINGTON, 2015)

Rosiglitazone, an agonist of peroxisome proliferator-activated receptor gamma, protects against gastric ischemia-reperfusion damage in rats: role of oxygen free radicals generation

Villegas, I; Martin, AR; Toma, W; de la Lastra, CA (Elsevier Science BvAmsterdamHolanda, 2004)

Structural Insights into Human Peroxisome Proliferator Activated Receptor Delta (PPAR-Delta) Selective Ligand Binding

Batista, Fernanda A. H.; Trivella, Daniela B. B.; Bernardes, Amanda; Gratieri, Joyce; Oliveira, Paulo S. L.; Figueira, Ana Carolina M.; Webb, Paul; Polikarpov, Igor (PUBLIC LIBRARY SCIENCESAN FRANCISCO, 2012)

Peroxisome proliferator activated receptors (PPARs delta, alpha and gamma) are closely related transcription factors that exert distinct effects on fatty acid and glucose metabolism, cardiac disease, inflammatory response ...

Molecular Mechanism of Peroxisome Proliferator-Activated Receptor alpha Activation by WY14643: a New Mode of Ligand Recognition and Receptor Stabilization

Bernardes, A; Souza, PCT; Muniz, JRC; Ricci, CG; Ayers, SD; Parekh, NM; Godoy, AS; Trivella, DBB; Reinach, P; Webb, P; Skaf, MS; Polikarpov, I (Academic Press Ltd- Elsevier Science LtdLondonInglaterra, 2013)

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