K V 3.1 blockers can serve as modulators of the rate of action potential firing in neurons with high rates of firing such as those of the auditory system. We studied the effects of several bioisosteres of N-alkylbenzenes ...

Potassium (K+) channels are part of one of the most abundant family of transmembrane proteins. K+ channels allow the selective transfer of K+ ions inside or outside of the cell. Within this family we find K2P channels, ...

TASK-­‐3 is a two-­‐pore domain potassium (K2P) channel highly expressed in hippocampus, cerebellum and cortex. TASK-­‐3 regulates neurotransmitter functions as well as the mediating effect of the neurotransmitter activa ...

The two-pore domain potassium (K2P) channel TASK-3 is a highly expressed in hippocampus, cerebellum and cortical areas of the brain. Besides regulating neurotransmitter functions, TASK-3 has an oncogenic potential and it ...

Two-­pore domain potassium (K2P) channels are expressed as functional dimers in the central nervous system, cardiovascular system, genitourinary system and gastrointestinal system. They are related with several pathologies ...

The isolation and structure elucidation of two novel nor-triterpenoid KV1.3 potassium channel blockers correolide and dehydrocorreolide from the Costa Rican tree Spachea correae are reported. The first potent and selective ...

Two-­pore domain potassium (K2P) channels trigger the background K+ currents in mammalian cells. K2P channels are separated into six subfamilies based on their structural and functional properties. The acid-­sensitive ...