Buscar

Mostrando ítems 1-1 de 1

Self-homodimerization of an actinoporin by disulfide bridging reveals implications for their structure and pore formation

Valle, Aisel; Pérez Socas, Luis Benito; Canet, Liem; Hervis, Yadira De La Patria; De Armas Guitart, German; Martins De Sa, Diogo; Lima, Jônatas Cunha Barbosa; Souza, Adolfo Carlos Barros; Barbosa, João Alexandre Ribeiro Gonçalves; De Freitas, Sonia Maria; Pazos, Isabel Fabiola (Nature Publishing Group, 2018-12)

The Trp111 to Cys mutant of sticholysin I, an actinoporin from Stichodactyla helianthus sea anemone, forms a homodimer via a disulfide bridge. The purified dimer is 193 times less hemolytic than the monomer. Ultracentrifugation, ...