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Inhibition of osteolysis and increase of bone formation after local administration of siRNA-targeting RANK in a polyethylene particle-induced osteolysis model
(Elsevier, 2015)
Receptor activator of nuclear factor kappa-B (RANK) and RANK-ligand are relevant targets for the treatment
of polyethylene particle-induced osteolysis. This study assessed the local administration of siRNA,
targeting ...
Titanium and zirconia particle-induced pro-inflammatory gene expression in cultured macrophages and osteolysis, inflammatory hyperalgesia and edema in vivo
(Pergamon-elsevier Science LtdOxfordInglaterra, 2014)
Orthopaedic implant failure: Aseptic implant loosening - the contribution and future challenges of mouse models in translational research
(Portland Press Ltd, 2015)
Aseptic loosening induced by UHMWPE wear particles is considered the main cause of longterm implant failure in orthopaedic surgery. The current therapy consists of surgical revision
and implant replacement, carrying severe ...
Mutant CCL2 protein coating mitigates wear particle-induced bone loss in a murine continuous polyethylene infusion model
(Elsevier Ltd, 2017)
Wear particle-induced osteolysis limits the long-term survivorship of total joint replacement (TJR). Monocyte/macrophages are the key cells of this adverse reaction. Monocyte Chemoattractant Protein-1 (MCP-1/CCL2) is the ...
NF-kappa B decoy oligodeoxynucleotide mitigates wear particle-associated bone loss in the murine continuous infusion model
(Elsevier, 2016)
Total joint replacement is a cost-effective surgical procedure for patients with end-stage arthritis. Wear particle-induced chronic inflammation is associated with the development of periprosthetic osteolysis. Modulation ...
Orthopaedic wear particle induced bone loss and exogenous macrophage infiltration is mitigated by local infusion of NF-kappa B decoy oligodeoxynucleotide
(Wiley, 2017)
Excessive production of wear particles from total joint replacements induces chronic inflammation, macrophage infiltration, and consequent bone loss (periprosthetic osteolysis). This inflammation and bone remodeling are ...
Orthopaedic wear particle-induced bone loss and exogenous macrophage infiltration is mitigated by local infusion of NF-jB decoy oligodeoxynucleotide
(Wiley, 2017)
Excessive production of wear particles from total joint replacements induces chronic inflammation, macrophage infiltration, and consequent bone loss (periprosthetic osteolysis). This inflammation and bone remodeling are ...
Orthopaedic wear particle-induced bone loss and exogenous macrophage infiltration is mitigated by local infusion of NF-κB decoy oligodeoxynucleotide
(John Wiley and Sons Inc., 2017)
Excessive production of wear particles from total joint replacements (TJRs) induces chronic
inflammation, macrophage infiltration, and consequent bone loss (periprosthetic osteolysis). This
inflammation and bone remodeling ...
DBBM shows no signs of resorption under inflammatory conditions. An experimental study in the mouse calvaria
(Wiley-Blackwell, 2019-09-30)
Objectives Deproteinized bovine bone mineral (DBBM) is not resorbable. However, the behavior of DBBM under inflammatory conditions remains unclear. Aim of the study was therefore to evaluate the resorption of DBBM under ...