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Current status and perspectives on the role of polyamines in plant immunity
(Wiley Blackwell Publishing, Inc, 2021-01)
Polyamines are low molecular weight amines, with versatile and essential functions during the lifespan of prokaryotes and eukaryotes. Modulation of polyamine metabolism under biotic stress has attracted a great deal of ...
Targeting polyamine transport in Trypanosoma cruzi
(Elsevier France-editions Scientifiques Medicales Elsevier, 2018-03)
Polyamines play critical roles as regulators of cell growth and differentiation. In contrast with other protozoa, the human parasite Trypanosoma cruzi, the etiological agent of Chagas disease, is auxotrophic for polyamines. ...
Identification of Trypanosoma cruzi Polyamine Transport Inhibitors by Computational Drug Repurposing
(Frontiers Research Foundation, 2019-10)
Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. In T. cruzi the transport of polyamines is essential because this organism is unable to synthesize these compounds ...
Pentamidine exerts in vitro and in vivo anti Trypanosoma cruzi activity and inhibits the polyamine transport in Trypanosoma cruzi
(Elsevier, 2014)
Pentamidine is an antiprotozoal and fungicide drug used in the treatment of leishmaniasis and African trypanosomiasis. Despite its extensive use as antiparasitic drug, little evidence exists about the effect of pentamidine ...
Amino acid and polyamine membrane transporters in Trypanosoma cruzi: biological function and evaluation as drug targets
(Bentham Science Publishers, 2019-12)
Amino acids and polyamines are involved in relevant processes for the parasite Trypanosoma cruzi, like protein synthesis, stress resistance, life cycle progression, infection establishment and redox balance, among others. ...
Techniques used for functional characterization of polyamine transporters
(Springer, 2018)
Transport systems are key processes in every living organism: they allow the entry of all essential nutrients into the cell and its compartments and regulate the intracellular concentrations of metabolites. The transport ...
Pentamidine exerts in vitro and in vivo anti Trypanosoma cruzi activity and inhibits the polyamine transport in Trypanosoma cruzi
(Elsevier Science, 2014-06)
Pentamidine is an antiprotozoal and fungicide drug used in the treatment of leishmaniasis and African trypanosomiasis. Despite its extensive use as antiparasitic drug, little evidence exists about the effect of pentamidine ...
Transporte e morfologia de esquemas de tintas epóxi poliamina equivalentes à base de solvente e água.
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-Graduação em Química - PPGQ, 2003-07-21)
In the present work, anticorrosive properties of solvent borne and water based epoxy polyamine coatings were studied comparatively. First these studies were performed for the individual layers of these coatings, i.e., ...
Key proteins in the polyamine-trypanothione pathway as drug targets against Trypanosoma cruzi
(Bentham Science Publishers B.V., 2014)
In trypanosomatids, redox homeostasis is centered on trypanothione (N 1,N8-bis(glutathionyl)spermidine, T(SH)2), a low molecular weight thiol that is distinctive for this taxonomic family and not present in the mammalian ...
Role of Polyamines in Parasite Cell Architecture and Function
(Bentham Science Publishers, 2018)