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Impact of the interplay between stemness features, p53 and pol iota on replication pathway choices
(Oxford University Press, 2021-07)
Using human embryonic, adult and cancer stem cells/stem cell-like cells (SCs), we demonstrate that DNA replication speed differs in SCs and their differentiated counterparts. While SCs decelerate DNA replication, differentiated ...
Kinase-independent function of checkpoint kinase 1 (Chk1) in the replication of damaged DNA
(National Academy of Sciences, 2012-05)
The checkpoint kinases Chk1 and ATR are broadly known for their role in the response to the accumulation of damaged DNA. Because Chk1 activation requires its phosphorylation by ATR, it is expected that ATR or Chk1 ...
The Tip of an Iceberg: Replication-Associated Functions of the Tumor Suppressor p53.
(MDPI, 2018-07)
The Tip of an Iceberg: Replication-Associated Functions of the Tumor Suppressor p53.Gottifredi V1, Wiesmüller L2.The tumor suppressor p53 is a transcriptional factor broadly mutated in cancer. Most inactivating and gain ...
Caracterización de foraminíferos bentónicos del núcleo NCS1, en el Atolón Cayo Serrana: Distribución, variabilidad y respuesta de estos ante eventos oceánicos extremos
(Facultad de Ciencias Exactas y NaturalesManizalesGeología, 2021)