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Metabolic profiling reveals that PNPLA3 induces widespread effects on metabolism beyond triacylglycerol remodeling in Huh-7 hepatoma cells
(American Physiological Society, 2014-07)
PNPLA3 was recently associated with the susceptibility to nonalcoholic fatty liver disease, a common cause of chronic liver disease characterized by abnormal triglyceride accumulation. Although it is established that PNPLA3 ...
Surviving your genes-the role of PNPLA3 variation in end-stage liver disease
(Wiley Blackwell Publishing, Inc, 2018-10)
PNPLA3, the history of an orphan gene of the potato tuber protein family that found an organ: the liver
(Wiley, 2014-06)
The patatin-like phospholipase domain containing 3 gene (PNPLA3) was an orphan gene looking for a disease until 2008 when the first genome-wide association study (GWAS) on nonalcoholic fatty liver disease (NAFLD) showed ...
Asociación entre el rs738409 del gen PNPLA3 y obesidad en jóvenes universitarios con hígado graso no alcohólico
(Universidad de Guayaquil. Facultad de Ciencias Químicas, 2018)
Introducción: El hígado graso no alcohólico y la obesidad son enfermedades muy comunes en la actualidad ambas son clasificas como enfermedades de tipo multifactorial. Objetivo: determinar la asociación que existe entre la ...
Impact of the association between PNPLA3 genetic variation and dietary intake on the risk of significant fibrosis in patients with NAFLD
(Nature Publishing Group, 2021-05-10)
INTRODUCTION: This study explored the relationship between patatin-like phospholipase domain-containing 3 gene (PNPLA3 rs738409), nutrient intake, and liver histology severity in patients with nonalcoholic fatty liver ...
Plasma and stool metabolomics to identify microbiota derived-biomarkers of metabolic dysfunction-associated fatty liver disease: effect of PNPLA3 genotype
(Springer, 2021-06)
Introduction: Non-invasive biomarkers are needed for metabolic dysfunction-associated fatty liver disease (MAFLD), especially for patients at risk of disease progression in high-prevalence areas. The microbiota and its ...
PNPLA3, the triacylglycerol synthesis/hydrolysis/storage dilemma, and nonalcoholic fatty liver disease
(W J G Press, 2012-11)
Genome-wide and candidate gene association studies have identified several variants that predispose individuals to developing nonalcoholic fatty liver disease (NAFLD). However, the gene that has been consistently involved ...
Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease
(Wiley, 2011-06)
Our objective was to estimate the strength of the effect of the I148M (rs738409 C/G) patatin-like phospholipase domain containing 3 (PNPLA3) variant on nonalcoholic fatty liver (NAFLD) and disease severity across different ...
Personalizing care for nonalcoholic fatty liver disease patients: what are the research priorities?
(Future Medicine, 2014-11)
Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease whose prevalence has reached global epidemic proportions, not only in adults but also in children. From a clinical point of view, NAFLD stems a ...