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Cost-effectiveness analysis of pneumococcal conjugate vaccines in preventing pneumonia in Peruvian children
(The Journal of Infection in Developing Countries, 2015-01-08)
Introduction: Pneumococcal pneumonia (PP) has a high burden of morbimortality in children. Use of pneumococcal conjugate vaccines (PCVs) is an effective preventive measure. After PCV 7-valent (PCV7) withdrawal, PCV 10-valent ...
Pneumolysin as a target for new therapies against pneumococcal infections: A systematic review
Background This systematic review evaluates pneumolysin (PLY) as a target for new treatments against pneumococcal infections. Pneumolysin is one of the main virulence factors produced by all types of pneumococci. This toxin ...
Invasive pneumococcal disease in hospitalised children from Lima, Peru before and after introduction of the 7-valent conjugated vaccine
(Cambridge University Press, 2019)
The objective of this study was to determine the serotype distribution and antibiotic resistance of invasive pneumococcal disease (IPD) strains in children from Lima, Peru, before and after the introduction of the 7-valent ...
Key features of invasive pneumococcal isolates recovered in Lima, Peru determined through whole genome sequencing
(Elsevier, 2017)
Before PCV7 introduction, invasive pneumococcal disease (IPD) was responsible for approximately 12,000-18,000 deaths annually among children <5years in Latin America. In Peru, PCV7 was introduced in 2009. We used whole ...
Host immunity in the protective response to nasal immunization with a pneumococcal antigen associated to live and heat-killed Lactobacillus casei
(BioMed Central, 2011-08-11)
Background: At present, available pneumococcal vaccines have failed to eradicate infections caused by S. pneumoniae. Search for effective vaccine continues and some serotype independent pneumococcal proteins are considered ...
Ineffectiveness for Infants of Immunization of Mothers with Pneumococcal Capsular Polysaccharide Vaccine During Pregnancy
(Contexto, 2009-04-01)
Pneumococcal (Pnc) carriage is associated with pneumococcal diseases. Breast feeding and maternal vaccination may be a useful approach to prevent pneumococcal infection in young infants. We examined the risk of Pnc carriage ...
Enhanced immune response to pneumococcal infection in malnourished mice nasally treated with heat-killed Lactobacillus casei
(Wiley Blackwell Publishing, Inc, 2009-11)
The present study analyzed whether nasal administration of viable and non-viable Lactobacillus casei CRL 431 to immunocompromised mice was capable of increasing resistance against Streptococcus pneumoniae. Weaned micewere ...
Enhanced immune response to pneumococcal infection in malnourished mice nasally treated with heat killed Lactobacillus casei
(Wiley Blackwell Publishing, Inc, 2009-07)
The present study analyzed whether nasal administration of viable and non-viable Lactobacillus casei CRL 431 to immunocompromised mice was capable of increasing resistance against Streptococcus pneumoniae. Weaned mice were ...
Resistance of Young Mice to Pneumococcal Infection can be Improved by Oral Vaccination with Recombinant Lactococcus lactis
(Elsevier, 2010-02)
Background/Purpose: Oral immunization with Lactococcus lactis PppA (LPA+), a recombinant strain that is able to express the pneumococcal protective protein A, can improve the resistance to respiratory challenge with ...