Buscar
Mostrando ítems 1-10 de 35
Platelet protease-activated receptor 1 and membrane expression of P-selectin in pulmonary arterial hypertension
(PERGAMON-ELSEVIER SCIENCE LTD, 2010)
Introduction: Pulmonary arterial hypertension (PAH) is frequently associated with thrombotic events, particularly involving the pulmonary microcirculation at sites of vascular injury. We therefore decided to analyse ...
Stimulation of PAR-1 or PAR-4 promotes similar pattern of VEGF and endostatin release and pro-angiogenic responses mediated by human platelets
(Taylor & Francis Ltd, 2015-06-17)
Background: Platelets mediate angiogenesis through the secretion of several factors, including the pro-angiogenic vascular endothelial growth factor (VEGF) and the anti-angiogenic endostatin. Although previous findings ...
Enzyme specificity and effects of gyroxin, a serine protease from the venom of the South American rattlesnake Crotalus durissus terrificus, on protease-activated receptors
(Elsevier B.V., 2014-03-01)
Gyroxin is a serine protease displaying a thrombin-like activity found in the venom of the South American rattlesnake Crotalus durissus terrificus. Typically, intravenous injection of purified gyroxin induces a barrel ...
Platelets: New bricks in the building of neutrophil extracellular traps
(Frontiers Research Foundation, 2016-07)
In addition to being key elements in hemostasis and thrombosis, platelets have an important role in the inflammatory and innate immune response. This activity is associated with their capability to recognize pathogens ...
Papel do Receptor Ativado por Protease (PAR)2 no recrutamento de neutrófilos induzido pelo Fator Ativador de Plaquetas (PAF)
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE FARMACOLOGIAPrograma de Pós-Graduação em Ciências Biológicas - Fisiologia e FarmacologiaUFMG, 2021-09-10)
At the lung inflammation microenvironment containing platelet-activating factor (PAF), proteases and protease-activated receptor (PAR)2 are also abundantly present. Despite this evidence, a cooperation between PAF and ...
Mechanisms of liver fibrosis associated with experimental fasciola hepatica infection: Roles of Fas2 proteinase and hepatic stellate cell activation
(American Society of Parasitologists, 2011)
We have evaluated the possible mechanisms of liver fibrosis caused by Fasciola hepatica in an animal model and in culture using immortalized human stellate cells. Liver biopsies of F. hepatica-infected rats were performed ...
Inibição do receptor tipo-1 ativado por protease (PAR¹) na doença e reparo periodontal
(Universidade Estadual Paulista (Unesp), 2012-03-20)
A sinalização celular por PAR¹ tem mostrado influenciar uma ampla gama de respostas patofisiológicas, incluindo ativação plaquetária, crescimento tumoral, inflamação e metástases. Baseando-se nisto, o objetivo do presente ...
Inibição do receptor tipo-1 ativado por protease (PAR¹) na doença e reparo periodontal
(Universidade Estadual Paulista (Unesp), 2012-03-20)
A sinalização celular por PAR¹ tem mostrado influenciar uma ampla gama de respostas patofisiológicas, incluindo ativação plaquetária, crescimento tumoral, inflamação e metástases. Baseando-se nisto, o objetivo do presente ...
Lactobacillus casei CRL431 modulates hemostatic activation induced by protein malnourishment and pneumococcal respiratory infection
(Springer, 2020-12-20)
Previously, we demonstrated that Lactobacillus casei CRL431, a well-known immunomodulatory bacterium, beneficially regulates coagulation activation, fibrin formation in lung, and the pro-inflammatory state induced by protein ...