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Commentary: Evidence for human transmission of amyloid-beta pathology and cerebral amyloid angiopathy
(Frontiers Media Sa, 2016)
Release of Acetylcholinesterase (AChE) from β-Amyloid plaques assemblies improves the spatial memory impairments in APP-transgenic mice
(2008)
The major protein constituent of amyloid deposits in Alzheimer's disease (AD) is the amyloid-beta-peptide (Abeta). Amyloid deposits contain "chaperone molecules" which play critical roles in amyloid formation and toxicity. ...
APOE and Alzheimer’s Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer’s Pathogenesis
(Humana Press Inc., 2019)
Microglia astrocyte interaction in Alzheimer's disease: friends or foes for the nervous system?
(Sociedad de Biología de Chile, 2001)
Amyloid Precursor Protein in Central and Peripheral Cholinergic Synaptopathies
(Nova Science Publishers, 2011-05)
Alzheimer´s disease is the most widespread form of dementia in the elderly. One of the characteristics of this disease is the profound functional deficit of the cholinergic system as a consequence of synaptic loss. Amyloid ...
Proinflammatory stimuli are needed for induction of microglial cell-mediated A beta PP244-C and A beta-neurotoxicity in hippocampal cultures
(IOS PRESS, 2008)
Amyloid-beta plaques and neurodegeneration are hallmarks of Alzheimer's disease, where glial cells are responsible for sustained neuroinflammation. Here we show that hippocampal-microglia co-cultures exposed to proinflammatory ...