Buscar
Mostrando ítems 1-10 de 290
The synthetic varespladib molecule is a multi-functional inhibitor for PLA2 and PLA2-like ophidic toxins
(2021-07-01)
Background: The treatment for snakebites is early administration of antivenom, which can be highly effective in inhibiting the systemic effects of snake venoms, but is less effective in the treatment of extra-circulatory ...
The synthetic Varespladib molecule is a multi-functional inhibitor for PLA2 and PLA2-like ophidic toxins
(2021)
The treatment for snakebites is early administration of antivenom, which can be highly effective in inhibiting the systemic effects of snake venoms, but is less effective in the treatment of extra-circulatory and local ...
PLA2-like proteins myotoxic mechanism: A dynamic model description
(2017-12-01)
Phospholipase A2-like (PLA2-like) proteins contribute to the development of muscle necrosis in Viperidae snake bites and are not efficiently neutralized by current antivenom treatments. The toxic mechanisms of PLA2-like ...
Functional and structural studies of a Phospholipase A2-like protein complexed to zinc ions: Insights on its myotoxicity and inhibition mechanism
(2017-01-01)
Background One of the main challenges in snakebite envenomation treatment is the development of stable, versatile and efficient anti-venom therapies. Local myotoxicity in accidents involving snakes from the Bothrops genus ...
Structural evidence for a fatty acid-independent myotoxic mechanism for a phospholipase A2-like toxin
(2018-03-01)
The myotoxic mechanism for PLA2-like toxins has been proposed recently to be initiated by an allosteric change induced by a fatty acid binding to the protein, leading to the alignment of the membrane docking site (MDoS) ...
Neutralization of a bothropic PLA2-like protein by caftaric acid, a novel potent inhibitor of ophidian myotoxicity
(2020-03-01)
Envenoming by snakebite is an important global health issue that has received little attention, leading the World Health Organization to naming it as neglected tropical disease. Several snakebites present serious local ...
Lys49 myotoxins, secreted phospholipase A2-like proteins of viperid venoms: a comprehensive review
(2023)
Muscle necrosis is a potential clinical complication of snakebite envenomings, which in severe cases can lead to functional or physical sequelae such as disability or amputation. Snake venom proteins with the ability to ...
Structural studies with BnSP-7 reveal an atypical oligomeric conformation compared to phospholipases A2-like toxins
(2017-11-01)
There are 2.5 million cases of snakebite per year and approximately 100,000 to 150,000 deaths. Thus, it is considered an important public health problem by the World Health Organization. Snakes from the Bothrops genus may ...
Structural basis for the inhibition of a phospholipase A2-like toxin by caffeic and aristolochic acids
(Public Library Science, 2015)
One of the main challenges in toxicology today is to develop therapeutic alternatives for the treatment of snake venom injuries that are not efficiently neutralized by conventional serum therapy. Venom phospholipases A2 ...
Estudos estruturais com miotoxinas fosfolipase a2-like isoladas e recombinante da peçonha de bothrops pauloensis
(Universidade Estadual Paulista (Unesp), 2020-02-28)
A toxicidade do veneno das serpentes do gênero Bothrops é resultante da ação integrada de várias toxinas, entre elas as fosfolipases A2 (PLA2s). Entre o grupo das PLA2s, há as PLA2s ativas enzimaticamente e as PLA2s ...