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Cellular and molecular specificity of pituitary gland physiology
(American Physiological Society, 2012-01)
The anterior pituitary gland has the ability to respond to complex signals derived from central and peripheral systems. Perception of these signals and their integration are mediated by cell interactions and cross-talk of ...
Cell life and death in the anterior pituitary gland: role of oestrogens
(Wiley, 2010-07)
Apoptotic processes play an important role in the maintenance of cell numbers in the anterior pituitary gland during physiological endocrine events. In this review, we summarise the regulation of apoptosis of anterior ...
Characterization of tachykinin NK2 receptor in the anterior pituitary gland
(Pergamon-Elsevier Science Ltd, 2003-09)
Tachykinins are a family of bioactive peptides that interact with three subtypes of receptors: NK1, NK2 and NK3. Substance P has greater affinity for NK1, and neurokinin A (NKA) for NK2 receptor subtype. Although only NK1 ...
Antiapoptotic factor humanin is expressed in normal and tumoral pituitary cells and protects them from TNF-α-induced apoptosis
(Public Library Of Science, 2014-10)
Humanin (HN) is a 24-amino acid peptide with cytoprotective action in several cell types such as neurons and testicular germ cells. Rattin (HNr), a homologous peptide of HN expressed in several adult rat tissues, also has ...
In vivo and in vitro arsenic exposition induces oxidative stress in anterior pituitary gland
(Sage Publications, 2016-04)
Inorganic arsenic (iAs) is at the top of toxic metalloids. Inorganic arsenic-contaminated water consumption is one of the greatest environmental health threats worldwide. Human iAs exposure has been associated with cancers ...
Cadmium induced-oxidative stress in pituitary gland is reversed by removing the contamination source
(Sage Publications, 2010-10)
Cadmium (Cd2+) is one of the most important environmental contaminants and acts as an endocrine disruptor. Previously, we have demonstrated that the simultaneous administration of Cd2+ and melatonin (Mel) in drinking water ...
Role of nitric oxide in the metabolism of arachidonic acid in the rat anterior pituitary gland
(Elsevier Ireland, 2001-02)
Nitric oxide (NO) affects cyclooxygenase (COX) and lipooxygenase (LOX) activities in several tissues. The aim of this study was to investigate the effect of NO on the AA metabolism in the anterior pituitary. LOX and COX ...
The phthalate DEHP modulates the estrogen receptors α and β increasing lactotroph cell population in female pituitary glands
(Pergamon-Elsevier Science Ltd, 2020-11)
Humans are exposed to numerous endocrine disruptors on a daily basis, which may interfere with endogenous estrogens, with Di-(2-ethylhexyl) phthalate (DEHP) being one of the most employed. The anterior pituitary gland is ...
Opposite effects of dihydrotestosterone and estradiol on apoptosis in the anterior pituitary gland from male rats
(Springer, 2016-03)
Hormones locally synthesized in the anterior pituitary gland are involved in regulation of pituitary cell renewal. In the pituitary, testosterone (T) may exert its actions per se or by conversion to dihydrotestosterone ...