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Leishmanicidal Effects of Piperlongumine (Piplartine) and Its Putative Metabolites

Moreira, Fernanda de Lima; Riul, Thalita Bachelli; Moreira, Marcela de Lima; Pilon, Alan Cesar; Dias-Baruffi, Marcelo; Araújo, Márcio Sobreira Silva; Lopes, Norberto Peporine; Oliveira, Anderson R M de (George Thieme, 2022)

Piperlongumine and some of its analogs inhibit selectively the human immunoproteasome over the constitutive proteasome

Inserm ERL1164; Universidade Estadual Paulista (Unesp); Universidade Federal do Rio de Janeiro (UFRJ); Universidade de São Paulo (USP) (2018-02-12)

The natural small molecule piperlongumine A is toxic selectively to cancer cells in vitro and in vivo. This toxicity has been correlated with cancer cell ROS, DNA damage and apoptotic cell death increases. We demonstrate ...

Synthetic analogue of the natural product piperlongumine as a potent inhibitor of breast cancer cell line migration

Universidade Estadual Paulista (Unesp); Universidade de São Paulo (USP); Universidade Estadual de Campinas (UNICAMP); Universidade Federal do Rio de Janeiro (UFRJ); Universitï¿½ Paris Descartes (2017-03-01)

Piperlongumine is a natural amide alkaloid isolated from several species of Piper and is described in the literature as selectively cytotoxic to several cancer cell lines. Inhibiting cell migration has gained considerable ...

Overview of the therapeutic potential of piplartine (piperlongumine)

Bezerra, Daniel Pereira; Pessoa, Claudia do Ó; Moraes Filho, Manoel Odorico de; Saker Neto, Nicolau; Silveira, Edilberto Rocha; Lotufo, Leticia Veras Costa (Elsevier, 2018)

An investigation into the interaction between piplartine (piperlongumine) and human serum albumin

Contessoto, Nayara Sousa de Alcântara; Caruso, Ícaro Putinhon; Bezerra, Daniel Pereira; Barbosa Filho, José Maria; Cornélio, Marinônio Lopes (Elsevier, 2019)

Synthesis and Spectroscopic Analysis of Piperine- and Piperlongumine-Inspired Natural Product Scaffolds and Their Molecular Docking with IL-1 beta and NF-kappa B Proteins

Universidade Estadual Paulista (Unesp); Univ Birmingham (Mdpi, 2020-06-01)

Inspired by the remarkable bioactivities exhibited by the natural products, piperine and piperlongumine, we synthesised eight natural product-inspired analogues to further investigate their structures. For the first time, ...

An investigation into the interaction between piplartine (piperlongumine)and human serum albumin

Universidade Estadual Paulista (Unesp); FIOCRUZ; Universidade Federal da Paraíba (UFPB) (2019-09-05)

Piplartines are alkaloid amides present in the roots and stems of different pepper species which have promising pharmacological properties including cancer prevention. Some recent studies have determined pharmacokinetic ...

Metabolic profile and safety of piperlongumine

Universidade de São Paulo (USP); Universidade Federal do Rio de Janeiro (UFRJ); Universidade Estadual Paulista (Unesp) (Nature Publishing Group, 2016-09-29)

Piperlongumine (PPL), a natural plant product, has been extensively studied in cancer treatment going up on clinical trials. Since the first report related to its use on cancer research (in 2011) around 80 papers have been ...

Unravelling the interaction of piperlongumine with the nucleotide-binding domain of hsp70: A spectroscopic and in silico study

Universidade Estadual Paulista (UNESP); University of Birmingham (2021-12-01)

Piperlongumine (PPL) is an alkaloid extracted from several pepper species that exhibits anti-inflammatory and anti-carcinogenic properties. Nevertheless, the molecular mode of action of PPL that confers such powerful ...

Details of the cooperative binding of piperlongumine with rat serum albumin obtained by spectroscopic and computational analyses

Universidade Estadual Paulista (Unesp) (2019-12-01)

Piperlongumine (PPL) has presented a variety of important pharmacological activities. In recent pharmacokinetics studies in rats, this molecule reached 76.39% of bioavailability. Although PPL is present in the bloodstream, ...