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Structural insights into the functional versatility of an FHA domain protein in mycobacterial signaling
(American Association for the Advancement of Science, 2019-05)
Forkhead-associated (FHA) domains are modules that bind to phosphothreonine (pThr) residues in signaling cascades. The FHA-containing mycobacterial protein GarA is a central element of a phosphorylation-dependent signaling ...
A connection between reversible tyrosine phosphorylation and SNARE complex disassembly activity of N-ethylmaleimide-sensitive factor unveiled by the phosphomimetic mutant N-ethylmaleimide-sensitive factor-Y83E
(Oxford University Press, 2019-07)
N-ethylmaleimide-sensitive factor (NSF) disassembles fusion-incompetent cis soluble-NSF attachment protein receptor (SNARE) complexes making monomeric SNAREs available for subsequent trans pairing and fusion. In most cells ...
Negative Modulation of Macroautophagy by Stabilized HERPUD1 is Counteracted by an Increased ER-Lysosomal Network With Impact in Drug-Induced Stress Cell Survival
(2022-03-02)
Macroautophagy and the ubiquitin proteasome system work as an interconnected network in the maintenance of cellular homeostasis. Indeed, efficient activation of macroautophagy upon nutritional deprivation is sustained by ...
Control de la Conductancia del Receptor GABAA por Residuos Intracelulares: Implicancias en la Regulación del Canal por Fosforilación.
(Universidad de Concepción.Facultad de Ciencias Biológicas, 2023)
Los receptores de ácido -aminobutírico tipo A (GABAARs) son los principales responsables de la neurotransmisión inhibitoria en el sistema nervioso central (SNC) en mamíferos. Estos receptores pertenecen a la familia de ...
Crosstalk between the serine/threonine kinase StkP and the response regulator ComE controls the stress response and intracellular survival of Streptococcus pneumoniae
(Public Library of Science, 2018-06)
Streptococcus pneumoniae is an opportunistic human bacterial pathogen that usually colonizes the upper respiratory tract, but the invasion and survival mechanism in respiratory epithelial cells remains elusive. Previously, ...
Phosphorylation or Mutation of the ERK2 Activation Loop Alters Oligonucleotide Binding
(American Chemical Society, 2016-03)
The mitogen-activated protein kinase ERK2 is able to elicit a wide range of context-specific responses to distinct stimuli, but the mechanisms underlying this versatility remain in question. Some cellular functions of ERK2 ...
Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells
(Elsevier, 2015)
A considerable body of evidence exists implicating high levels of free saturated fatty acids in beta pancreatic cell
death, although the molecular mechanisms and the signaling pathways involved have not been clearly ...
Cdk5 Regulation of the GRAB-Mediated Rab8-Rab11 Cascade in Axon Outgrowth
(Society for Neuroscience, 2017)
Neurons communicate with each other through their axons and dendrites. However, a full characterization of the molecular mechanisms
involved in axon and dendrite formation is still incomplete. Neurite outgrowth requires ...
Casein kinase-mediated phosphorylation of serine 839 is necessary for basolateral localization of the Ca2+-activated non-selective cation channel TRPM4
(Springer, 2015)
Transient receptor potential melastatin-like 4 (TRPM4) is a Ca2+-activated non-selective cation channel expressed in a wide range of human tissues. TRPM4 participates in a variety of physiological processes such as T cell ...