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Synthesis and evaluation of new heteroaryl nitrones with spin trap properties
(Royal Society of Chemistry, 2020-11)
A new series of heteroaryl nitrones were synthesized and evaluated as free radical traps due to the results showed in our previous report. The physicochemical characterization of these new nitrones by electron spin resonance ...
Heteroarylnitrones as Drugs for Neurodegenerative Diseases: Synthesis, Neuroprotective Properties, and Free Radical Scavenger Properties
(American Chemical Society, 2008-09)
New 1,2,4-thiadiazolylnitrones and furoxanylnitrones were developed and evaluated as neuroprotective agents
on a human neuroblastoma (SH-SY5Y) cells model. They inhibited at low micromolar concentrations the
oxidative ...
Joint Theoretical Experimental Investigation of the Electron Spin Resonance Spectra of Nitroxyl Radicals: Application to Intermediates in in Situ Nitroxide Mediated Polymerization (In Situ NMP) of Vinyl Monomers
(American Chemical Society, 2008-08)
Density functional theory (DFT) calculations have been performed to address the structure of nitroxide intermediates in controlled radical polymerization. In a preliminary step, the reliability of different theoretical ...
Nitrones: a potential new alternative as therapeutic agents
(Bentham Science Publishers Ltd., 2017)
Background: Nowadays, nitrones are the most used spin traps to characterize free radicals in biological systems due to the versatility and variety depending on the types of radicals to study and that the half-lives of the ...
A molecular electron density theory study of the [3 + 2] cycloaddition reaction of nitrones with strained allenes
(Royal Society of Chemistry, 2017)
The [3 + 2] cycloaddition (32CA) reaction of C-phenyl-N-tert-butylnitrone with 1,2-cyclohexadiene (CHDE), a strained allene, has been studied within Molecular Electron Density Theory (MEDT) at the DFT B3LYP/6-311G(d,p) ...