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TRPC6 regulates phenotypic switching of vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN
(Federation of American Societies for Experimental Biology, 2019-09)
Vascular smooth muscle cells (VSMCs) play critical roles in the stability and tonic regulation of vascular homeostasis. VSMCs can switch back and forth between highly proliferative synthetic and fully differentiated ...
Protein conformational dynamics and phenotypic switching
(2021-01-01)
Intrinsically disordered proteins (IDPs) are proteins that lack rigid 3D structure but exist as conformational ensembles. Because of their structural plasticity, they can interact with multiple partners. The protein ...
TRPC6 regulates phenotypic switching of vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN
(Federation of American Societies for Experimental Biology, 2020)
Macrophage polarization: implications on metabolic diseases and the role of exercise
(Consel Brasil Oftalmologia, 2016)
Macrophages are cells of the innate immune response that trigger inflammation resolution. The phenotype of "classically activated macrophages" (M1) has anti-tumoricidal and anti-bactericidal activities. On the other hand, ...
Slug is increased in vascular remodeling and induces a smooth muscle cell proliferative phenotype
(Public Library of Science, 2016-07)
Objective : Previous studies have confirmed Slug as a key player in regulating phenotypic changes in several cell models, however, its role in smooth muscle cells (SMC) has never been assessed. The purpose of this study ...
Canonical transient receptor potential 6 channel deficiency promotes smooth muscle cells dedifferentiation and increased proliferation after arterial injury
(Elsevier, 2020-07)
Objective Previous studies showed the benefit of canonical transient receptor potential 6 (TRPC6) channel deficiency in promoting endothelial healing of arterial injuries in hypercholesterolemic animals. Long-term studies ...
Autophagy mediates tumor necrosis factor-α-induced phenotype switching in vascular smooth muscle A7r5 cell line
(Public Library of Science, 2018)
This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the ...
The role of VEGF-R3 pathway switch induced by M2-like tumour associated macrophages on the development of a pro-metastatic phenotype in papillary thyroid carcinoma
(2020)
Cancer is the second leading cause of death globally. The major determinant of mortality in cancer patients is the presence of distant organ metastasis, and one of the most important clinical risk factors is the compromise ...
Noninfectious complications in patients with pediatric-onset common variable immunodeficiency correlated with defects in somatic hypermutation but not in class-switch recombination
(Mosby-Elsevier, 2017-03)
Background Common variable immunodeficiency (CVID) is a heterogeneous syndrome characterized by impaired immunoglobulin production and usually presents with a normal quantity of peripheral B cells. Most attempts aiming to ...