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Medicinal chemistry targeting mitochondria: From new vehicles and pharmacophore groups to old drugs with mitochondrial activity
(MDPI, 2020)
Interest in tumor cell mitochondria as a pharmacological target has been rekindled in recent years. This attention is due in part to new publications documenting heterogenous characteristics of solid tumors, including ...
Molecular hybridization: A useful tool in the design of new drug prototypes
(2007-07-01)
Molecular hybridization is a new concept in drug design and development based on the combination of pharmacophoric moieties of different bioactive substances to produce a new hyrid compound with improved affinity and ...
Molecular hybridization: A useful tool in the design of new drug prototypes
(2007-07-01)
Molecular hybridization is a new concept in drug design and development based on the combination of pharmacophoric moieties of different bioactive substances to produce a new hyrid compound with improved affinity and ...
A DFT study of the relationships between electronic structure and peripheral benzodiazepine receptor affinity in a group of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides
(SOC CHILENA QUIMICA, 2010-07-12)
We present here the results of a Density Functional Theory study of the relationships between electronic structure and peripheral benzodiazepine receptor
affinity for a group of N,N-dialkyl-2-phenylindol-3-ylglyoxylamide ...
A dft study of the relationships between electronic structure and peripheral benzodiazepine receptor affinity in a group of N,N-dialkyl-2- phenylind0l-3-ylglyoxylamides
(Sociedad Chilena de Quimica, 2010)
We present here the results of a Density Functional Theory study of the relationships between electronic structure and peripheral benzodiazepine receptor affinity for a group of N,N-dialkyl-2-phenylindol-3-ylglyoxylamide ...
In vitro activity and mechanism of action against the protozoan parasite Trypanosoma cruzi of 5-nitrofuryl containing thiosemicarbazones
(PERGAMON-ELSEVIER SCIENCE LTD, 2004-09-15)
The in vitro growth inhibition activity of new thiosemicarbazone derivatives against the protozoan parasite Trypanosoma cruzi, the causative agent of American trypanosomiasis, are described. The designed compounds combine ...
Prediction of drug targets in human pathogens
(Universidade Federal de Minas GeraisUFMG, 2017-02-21)
The rapid emergence of resistant bacteria makes today's antibiotics more and more ineffective, consequently increasing the need for new pharmacological targets and novel classes of antibacterial drugs. The identification ...
Nitrofuran drugs beyond redox cycling: Evidence of Nitroreduction-independent cytotoxicity mechanism
(Elsevier, 2020)
Nitrofurans (5-nitro-2-hydrazonylfuran as pharmacophore) are a group of widely used antimicrobial drugs but also associated to a variety of side effects. The molecular mechanisms that underlie the cytotoxic effects of ...