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Network pharmacology and epilepsy
(Springer, 2016)
In contrast with the reductionist “one gene, one target, one drug” approach, network pharmacology proposes the use of multi-target therapies, a strategy that seems particularly suitable to treat disorders of complex etiology, ...
Pharmacological targeting of adenosine receptor signaling
(2017)
Adenosine receptor signaling plays important roles in normal physiology, but is also known to modulate the development or progression of several different diseases. The design of new, efficient, and safe pharmacological ...
Multi-target pharmacology: Possibilities and limitations of the "skeleton key approach" from a medicinal chemist perspective
(Frontiers Research Foundation, 2015-09)
Multi-target drugs have raised considerable interest in the last decade owing to their advantages in the treatment of complex diseases and health conditions linked to drug resistance issues. Prospective drug repositioning ...
Therapeutic targeting of autophagy in myocardial infarction and heart failure
(Taylor & Francis, 2016)
Introduction: Myocardial infarction (MI) is the leading cause of death. When MI is not lethal, heart failure (HF) is a major consequence with high prevalence and poor prognosis. The targeting of autophagy represents a ...
Tailored Multi-Target Agents: Applications and Design Considerations
(Bentham Science Publishers, 2016-03)
In contrast to the one target-one drug model, multi-target agents seem as a promising alternative to manage complex disorders and health conditions linked to drug resistance issues. In fact, many longstanding drugs are in ...
Potential compound from herbal food of rhizoma polygonati for treatment of COVID-19 analyzed by network pharmacology and molecular docking tech- nology
Rhizoma Polygonati (huangjing in Chinese, 黄精) is an herb-homology-food used as
a component of alternative medicine treating COVID-19 in the current pandemic
emergency in China but the mechanisms remain elusive. Here using ...
The efficiency of multi-target drugs: A network approach
(Springer, 2020)
Multi-target agents have attracted great attention in the last 15 years, as they are expected to provide more efficacious and safer therapeutic solutions, less prone to drug resistance phenomena. They thus seem particularly ...
Entinostat (SNDX-275) for the treatment of non-small cell lung cancer
(Taylor and Francis, 2015)
INTRODUCTION: Epigenetic aberrations play an important role in lung carcinogenesis. Chromatin deacetylation is a fundamental mechanism of gene silencing. Histone deacetylase (HDAC) inhibitors are an emerging class of ...
Natural isoquinoline alkaloids: Pharmacological features and multi-target potential for complex diseases
(2022)
Complex diseases such as neurodegenerative disorders and cancer constitute a growing public health problem due to the rising incidence and lack in effective therapies. Since pharmacotherapy based on a single target has ...