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Peripheral kappa and delta opioid receptors are involved in the antinociceptive effect of crotalphine in a rat model of cancer pain
(2013-06-17)
Cancer pain is an important clinical problem and may not respond satisfactorily to the current analgesic therapy. We have characterized a novel and potent analgesic peptide, crotalphine, from the venom of the South American ...
Peripheral kappa and delta opioid receptors are involved in the antinociceptive effect of crotalphine in a rat model of cancer pain
(2013-06-17)
Cancer pain is an important clinical problem and may not respond satisfactorily to the current analgesic therapy. We have characterized a novel and potent analgesic peptide, crotalphine, from the venom of the South American ...
Crotalphine induces potent antinociception in neuropathic pain by acting at peripheral opioid receptors
(ELSEVIER SCIENCE BV, 2008)
Neuropathic pain is an important clinical problem and it is usually resistant to the current therapy. We have recently characterized a novel analgesic peptide, crotalphine, from the venom of the South American rattlesnake ...
Serotonin induces peripheral antinociception via the opioidergic system
(Universidade Federal de Minas GeraisBrasilFAE - FACULDADE DE EDUCAÇÃOUFMG, 2017)
Objetivo
Estudos realizados desde 1969 mostraram que a liberação de serotonina (5-HT) no corno dorsal da medula espinhal contribui para a analgesia opióide. No presente estudo, foi examinada a participação do sistema ...
The peripheral L-arginine-nitric oxide-cyclic GMP pathway and ATP-sensitive K+ channels are involved in the antinociceptive effect of crotalphine on neuropathic pain in rats
(LIPPINCOTT WILLIAMS & WILKINSPHILADELPHIA, 2012)
Crotalphine, a 14 amino acid peptide first isolated from the venom of the South American rattlesnake Crotalus durissus terrificus, induces a peripheral long-lasting and opioid receptor-mediated antinociceptive effect in a ...
Antinociception induced by rosuvastatin in murine neuropathic pain
(Elsevier, 2018-06)
Background: Neuropathic pain, and subsequent hypernociception, can be induced in mice by paclitaxel (PTX) administration and partial sciatic nerve ligation (PSNL). Its pharmacotherapy has been a clinical challenge, due to ...
Anti-inflammatory and antinociceptive activities of Loasa speciosa in rats and mice
(Elsevier, 2003)
In the range of doses of 250–500 mgykg (given i.p.) the aqueous extract of Loasa speciosa leaves showed an inhibitory effect on leukocyte migration, and a reduction on the pleural exudate, as well as dose-dependent ...
Antinociceptive action of hemopressin in experimental hyperalgesia
(Elsevier Science IncNew YorkEUA, 2005)