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New perspective on the pathophysiology of panic: merging serotonin and opioids in the periaqueductal gray
(Associação Brasileira de Divulgação Científica, 2012)
Panic disorder patients are vulnerable to recurrent panic attacks. Two neurochemical hypotheses have been proposed to explain this susceptibility. The first assumes that panic patients have deficient serotonergic inhibition ...
Organization of electrically and chemically evoked defensive behaviors within the deeper collicular layers as compared to the periaqueductal gray matter of the rat
(Elsevier B.V., 2005-01-01)
Stimulation of the periaqueductal gray matter (PAG) and the deeper layers of superior colliculus (SC) produces both freezing (tense immobility) and flight (trotting, galloping and jumping) behaviors along With exophthalmus ...
The ventrolateral periaqueductal gray is involved in the cardiovascular response evoked by L-glutamate microinjection into the lateral hypothalamus of anesthetized rats
(ELSEVIER IRELAND LTD, 2008)
Microinjection Of L-glutamate (L-glu: 1, 3, 10 and 30nmol/100nL) into the lateral hypothalamus (LH) caused dose-related depressor and bradycardiac responses. The cardiovascular response to L-glu stimulation of the LH was ...
Inactivation of the dorsolateral periaqueductal gray matter impairs the promoting influence of stress on fear memory during retrieval
(Springer Heidelberg, 2019-11)
Exposure to stressful conditions induces long-lasting neurobiological changes in selected brain areas, which could be associated with the emergence of negative emotional responses. Moreover, the interaction of a stressful ...
Anxiogenic-like effect induced by TRPV1 receptor activation within the dorsal periaqueductal gray matter in mice
(2013-08-01)
Pharmacological manipulation of TRPV1 (Transient Receptor Potential Vanilloid type-1) receptors has been emerging as a novel target in the investigation of anxiety states. Here, we attempt to show the role played by the ...
Anxiogenic-like effect induced by TRPV1 receptor activation within the dorsal periaqueductal gray matter in mice
(2013-08-01)
Pharmacological manipulation of TRPV1 (Transient Receptor Potential Vanilloid type-1) receptors has been emerging as a novel target in the investigation of anxiety states. Here, we attempt to show the role played by the ...
Functional mapping of the periaqueductal gray matter involved in organizing tonic immobility behavior in guinea pigs
(ELSEVIER SCIENCE BV, 2011)
Tonic immobility behavior (TI) is an innate response characterized by profound motor inhibition that is exhibited by prey when physical contact with a predator is prolonged and the situation inescapable. The periaqueductal ...
GLUTAMATERGIC MECHANISMS OF THE DORSAL PERIAQUEDUCTAL GRAY MATTER MODULATE THE EXPRESSION OF CONDITIONED FREEZING AND FEAR-POTENTIATED STARTLE
(PERGAMON-ELSEVIER SCIENCE LTDOXFORD, 2013-08-02)
It is well known that excitatory amino acids induce unconditioned fear responses when locally injected into the dorsal periaqueductal gray matter (dPAG). However, there are only few studies about the involvement of excitatory ...
ON THE VERGE OF A RESPIRATORY-TYPE PANIC ATTACK: SELECTIVE ACTIVATIONS OF ROSTROLATERAL AND CAUDOVENTROLATERAL PERIAQUEDUCTAL GRAY MATTER FOLLOWING SHORT-LASTING ESCAPE TO A LOW DOSE OF POTASSIUM CYANIDE
(Pergamon-Elsevier Science Ltd, 2017)
Intravenous injections of potassium cyanide (KCN) both elicit escape by its own and facilitate escape to electrical stimulation of the periaqueductal gray matter (PAG). Moreover, whereas the KCN-evoked escape is potentiated ...