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Monitoring the positioning of short polycationic peptides in model lipid bilayers by combining hydrogen/deuterium exchange and electrospray ionization mass spectrometry
(Elsevier B.V., 2008-12-01)
Electrospray ionization mass spectrometry (ESI-MS) was used to analyze the hydrogen/deuterium exchange properties of the mastoparan peptide Apoica-MP during interactions with lipid vesicle membranes. Synthetic peptide was ...
Monitoring the positioning of short polycationic peptides in model lipid bilayers by combining hydrogen/deuterium exchange and electrospray ionization mass spectrometry
(Elsevier B.V., 2008-12-01)
Electrospray ionization mass spectrometry (ESI-MS) was used to analyze the hydrogen/deuterium exchange properties of the mastoparan peptide Apoica-MP during interactions with lipid vesicle membranes. Synthetic peptide was ...
Transmembrane domain dimerization induces cholesterol rafts in curved lipid bilayers
(Royal Society of Chemistry, 2019-01)
Are the dimerization of transmembrane (TM) domains and the reorganization of the lipid bilayer two independent events? Does one event induce or interfere with the other? In this work, we have performed well-tempered ...
The effect of pH on the lytic activity of a synthetic mastoparan-like peptide in anionic model membranes
(2018-11-01)
Peptide sequences containing acidic and basic residues could potentially have their net charges modulated by bulk pH with a possible influence on their lytic activity in lipid vesicles. The present study reports on a ...
Differential interaction of antimicrobial peptides with lipid structures studied by coarse-grained molecular dynamics simulations
(Molecular Diversity Preservation International, 2017-10)
In this work; we investigated the differential interaction of amphiphilic antimicrobial peptides with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) lipid structures by means of extensive molecular dynamics ...
EFFECT OF HEAD GROUP AND CURVATURE ON BINDING OF THE ANTIMICROBIAL PEPTIDE TRITRPTICIN TO LIPID MEMBRANES
(ELSEVIER IRELAND LTDCLARE, 2012)
In this work we examine the interaction between the 13-residue cationic antimicrobial peptide (AMP) tritrpticin (VRRFPWWWPFLRR, TRP3) and model membranes of variable lipid composition. The effect on peptide conformational ...
Membrane targeting peptides toward antileishmanial activity: Design, structural determination and mechanism of interaction
(Elsevier B.V., 2017-11-01)
Background: Leishmaniasis threatens poor areas population worldwide, requiring new drugs less prone to resistance development. Antimicrobial peptides with antileishmanial activity are considered among fulfilling alternatives, ...
Saddle-curvature instability of lipid bilayer induced by amphipathic peptides: a molecular model
(2020-06-07)
Amphipathic peptides that partition into lipid bilayers affect the curvature elastic properties of their host. Some of these peptides are able to shift the Gaussian modulus to positive values, thus triggering an instability ...
Peptide-lipid interaction monitored by spin labeled biologically active melanocortin peptides
(Elsevier B.V., 2005-10-01)
The present work comparatively analyzes the interaction of alpha-MSH and its more potent and long-acting analog [Nle(4), D-Phe(7)]alpha-MSH (NDP-MSH) with lipid bilayers. the peptides were spin labeled with Toac ...
Chitosan derivatives targeting lipid bilayers: Synthesis, biological activity and interaction with model membranes
(2017-01-01)
The antimicrobial activity of chitosan and derivatives to human and plant pathogens represents a high-valued prospective market. Presently, two low molecular weight derivatives, endowed with hydrophobic and cationic character ...