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Assessment of the percutaneous penetration of cisplatin: The effect of monoolein and the drug skin penetration pathway
(ELSEVIER SCIENCE BV, 2009)
It was intended to examine the in vitro penetration of cisplatin (CIS) through porcine skin in the presence of different concentrations of monoolein (MO) as well as to verify the main barrier for CIS skin penetration. In ...
Liposomes can both enhance or reduce drugs penetration through the skin
(Nature Publishing Group, 2018-12)
The adequate formulation of topical vehicles to treat skin diseases is particularly complex. A desirable formulation should enhance the accumulation of the active drugs in the target tissue (the skin), while avoiding the ...
Enhanced skin penetration of P20 phosphopeptide using protein transduction domains
(ELSEVIER SCIENCE BV, 2008)
Protein transduction domains (PTDs) were recently demonstrated to increase the penetration of the model peptide P20 when the PTD and P20 were covalently attached. Here, we evaluated whether non-covalently linked PTDs were ...
Long‐duration penetration of the interplanetary electric field to the low‐latitude ionosphere during the main phase of magnetic storms
(American Geophysical Union, 2005-11-26)
It is well known that the interplanetary electric field can penetrate to the low‐latitude ionosphere. It is generally believed that the penetration of electric fields can last only for ∼30 min because of the shielding ...
Modification of the linker amino acid in the cell-penetrating peptide NickFect55 leads to enhanced pDNA transfection for in vivo applications
(MDPI, 2023-02-20)
Despite numerous efforts over the last three decades, nucleic acid-based therapeutics still lack delivery platforms in the clinical stage. Cell-penetrating peptides (CPPs) may offer solutions as potential delivery vectors. ...
In vitro evaluation of copaiba oil as a kojic acid skin enhancer
(Univ Sao Paulo, Conjunto QuimicasSao PauloBrasil, 2010)
The topical nanodelivery of vismodegib enhances its skin penetration and performance in vitro while reducing its toxicity in vivo
(Multidisciplinary Digital Publishing Institute, 2021-01)
Vismodegib is a first-in-class inhibitor for advanced basal cell carcinoma treatment. Its daily oral doses present a high distribution volume and several side effects. We evaluated its skin penetration loaded in diverse ...
The Use of Nanotechnology in Cosmetic Formulations: The Influence of Vehicle in the Vitamin A Skin Penetration
(BENTHAM SCIENCE PUBL LTDSHARJAH, 2013-08-02)
Despite the efficacy of topical retinoic acid, skin reactions have limited its acceptance by patients. Other retinoids, like Retinyl Palmitate (RP), are considerably less irritating, but they are also less effective. In ...
Sporadic E layer development and disruption at low latitudes by prompt penetration electric fields during magnetic storms
(American Geophysical Union, 2013-04-11)
An investigation of low‐latitude sporadic E layers during magnetic storms shows that the formation and disruption of these layers are strongly controlled by the magnetospheric electric fields that penetrate to equatorial ...