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Validação de método de separação e análise de vesículas extracelulares humanas oriundas de camundongos imunodeficientes com carcinoma de células renais

Vittoria Riva Zampetti (2022)

Combined Microdialysis-Tumor Homogenate Method for the Study of the Steady State Compartmental Distribution of a Hydrophobic Anticancer Drug in Patient-Derived Xenografts

Monterrubio, Carles; Paco, Sonia; Vila Ubach, Mónica; Rodríguez, Eva; Glisoni, Romina Julieta; Lavarino, Cinzia; Schaiquevich, Paula Susana; Sosnik, Alejandro; Mora, Jaume; Carcaboso, Ángel M. (Springer, 2014-03)

PURPOSE: To develop a reproducible microdialysis-tumor homogenate method for the study of the intratumor distribution of a highly hydrophobic anticancer drug (SN-38; 7-ethyl-10-hydroxycamptothecin) in neuroblastoma ...

Next-generation sequencing analysis and algorithms for PDX and CDX models

Khandelwal, Garima; Girotti, Maria Romina; Smowton, Christopher; Taylor, Sam; Wirth, Christopher; Dynowski, Marek; Frese, Kristopher K.; Brady, Ged; Dive, Caroline; Marais, Richard; Miller, Crispin (American Association for Cancer Research, 2017-04-25)

Patient-derived xenograft (PDX) and CTC-derived explant (CDX) models are powerful methods for the study of human disease. In cancer research, these methods have been applied to multiple questions including the study of ...

Targeted drug distribution in tumor extracellular fluid of GD2-expressing neuroblastoma patient-derived xenografts using SN-38-loaded nanoparticles conjugated to the monoclonal antibody 3F8

Monterrubio, Carles; Paco, Sonia; Olaciregui, Nagore G.; Pascual Pasto, Guillem; Vila Ubach, Monica; Cuadrado Vilanova, Maria; Ferrandiz, M. Mar; Castillo Ecija, Helena; Glisoni, Romina Julieta; Kuplennik, Nataliya; Jungbluth, Achim; de Torres, Carmen; Lavarino, Cinzia; Cheung, N. K. V.; Mora, Jaume; Sosnik, Alejandro Dario; Montero Carcaboso, Angel (Elsevier Science, 2017-06)

Neuroblastoma is a pediatric solid tumor with high expression of the tumor associated antigen disialoganglioside GD2. Despite initial response to induction therapy, nearly 50% of high-risk neuroblastomas recur because of ...

Generación de modelos de xenoinjerto derivados de pacientes (PDX) portadores de cáncer cervicouterino avanzado y evaluación de la eficacia antitumoral de la terapia antisentido

Guevara Sepúlveda, Francisca Soledad (Universidad Andrés Bello, 2018)

El cáncer cervicouterino (CaCu) es uno de los cánceres diagnosticado con mayor frecuencia en mujeres, junto con el de mama y estómago. En Chile, cerca de 1.441 nuevos casos son diagnosticados anualmente con una tasa de ...

Estabelecimento e caracterização de um modelo in vivo e in vitro de mixoma odontogênico

Juliana Cristina de Souza (Universidade Federal de Minas GeraisBrasilMEDICINA - FACULDADE DE MEDICINAPrograma de Pós-Graduação em Medicina MolecularUFMG, 2021-05-03)

Odontogenic myxoma (OM) is a rare intraosseous neoplasm. Despite being benign, OM has an aggressive behavior and is locally infiltrative, which can cause facial deformities and impact patient’s quality of life. In addition, ...

Efeito do peptídeo ligante de heparam sulfato na progressão tumoral

Melo, Carina Mucciolo [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2018-02-22)

Heparan sulfate (HS) is widely distributed and evolutionarily conserved, a fact that dates back to the vital importance of this molecule in cell development and functions such as cell proliferation, migration, adhesion, ...

Leukaemia Inhibitory Factor (LIF) inhibits cancer stem cells tumorigenic properties through hippo kinases activation in gastric cancer

Seeneevassen, Lornella; Giraud, Julie; Molina Castro, Silvia Elena; Sifré, Elodie; Tiffon, Camille; Beauvoit, Clémentine; Staedel, Cathy; Mégraud, Francis; Lethours, Philippe; Martin, Océane C.B.; Boeuf, Hélène; Dubus, Pierre; Varon, Christine (2020)

Cancer stem cells (CSCs) present chemo-resistance mechanisms contributing to tumour maintenance and recurrence, making their targeting of utmost importance in gastric cancer (GC) therapy. The Hippo pathway has been ...