Background During the last decade, with the aim to solve the challenge of post-genomic and transcriptomic data mining, a plethora of tools have been developed to create, edit and analyze metabolic pathways. In particular, ...

Background: We are living in an era that is in general characterized by a lot of data but little information. An enormous amount of biological data collected over several years is now presented as annotations and databases. ...

Microorganisms have the ability to adapt and respond to different environmental conditions, whether they are stressful or not. Although the detection and/or responding mechanisms are often unknown, a large number of proteins ...

Background: The development of high-throughput omics technologies enabled genome-wide measurements of the activity of cellular elements and provides the analytical resources for the progress of the Systems Biology discipline. ...

Signaling pathways are responsible for the regulation of cell processes, such as monitoring the external environment, transmitting information across membranes, and making cell fate decisions. Given the increasing amount ...

Glutamine (GLN) avoids the inhibition of the intestinal Ca2+ absorption caused by menadione (MEN) through oxidative stress. The purpose of this study was to elucidate whether molecules of transcellular and/or paracellular ...

Preferential fluid pathways along regional fault systems are crucial for the spatial localization of volcanic and geothermal manifestations. Differences in electric properties of fluids and hydrothermal alteration products ...

Process mining of routine electronic healthcare records can help inform the management of care pathways. Combining process mining with simulation creates a rich set of tools for care pathway improvement. Healthcare process ...