Buscar
Mostrando ítems 1-10 de 58
Search for Novel Potent Inhibitors of the SARS-CoV-2 Papain-like Enzyme: A Computational Biochemistry Approach
(MDPI, 2022-08)
The rapid emergence and spread of new variants of coronavirus type 2, as well as the emergence of zoonotic viruses, highlights the need for methodologies that contribute to the search for new pharmacological treatments. ...
Cysteine proteinase activity regulation - A possible role of heparin and heparin-like glycosaminoglycans
(Amer Soc Biochemistry Molecular Biology Inc, 1999-10-22)
Papain is considered to be the archetype of cysteine proteinases. the interaction of heparin and other glycosaminoglycans with papain may be representative of many mammalian cysteine proteinase-glycosaminoglycan interactions ...
Purification and characterization of two cysteine peptidases of the Mediterranean fruit fly Ceratitis capitata during metamorphosis
(Wiley, 2008-05)
In holometabolous insects, there is a complete body remodeling from larva to adult. We determined in Ceratitis capitata that the transition from pre-pupa to pupa, 40 to 48 h after puparium formation (h APF), is a key moment ...
Papaína imobilizada em partículas magnéticas: novos modelos de triagem de ligantes
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Química - PPGQCâmpus São Carlos, 2019-03-29)
Cathepsins, human lysosomal enzymes, are associated with the development of various diseases, and cruzaine is an important enzyme in the development of the protozoan Trypanosoma cruzi, causes Chagas' disease. Cysteine ...
Study of phytoproteases stability in aqueous-organic biphasic systems using linear free energy relationships
(Elsevier Science, 2006-02)
In this paper we study the effect of different water-immiscible organic solvents (benzene, toluene, 1-butanol, 1-octanol, dichloroethane, dichloromethane, diethyl ether, hexane, chlorobenzene, acetophenone, n-dodecane, ...