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Beneficial and Detrimental Remodeling of Glial Connexin and Pannexin Functions in Rodent Models of Nervous System Diseases
(Frontiers Media S.A., 2019-11)
A variety of glial cell functions are supported by connexin and pannexin proteins. These functions include the modulation of synaptic gain, the control of excitability through regulation of the ion and neurotransmitter ...
Genetic ablation of pannexin1 counteracts liver fibrosis in a chemical, but not in a surgical mouse model
(2018-08-01)
Liver fibrosis is the final common pathway for almost all causes of chronic liver injury. This chronic disease is characterized by excessive deposition of extracellular matrix components mainly due to transdifferentiation ...
Connexin hemichannels and pannexin channels contributes to the intracellular Ca2+ signal activated by PAF in endothelial cells of mesenteric post-capillary venules
(2016)
Endothelial cells form a permeability barrier to macromolecules that can be modulated in post-capillary venules through the activation of Ca2+-dependent signaling pathways by pro-inflammatory agents, such as platelet-activating ...
Gap junction channels and hemichannels in the CNS: regulation by signaling molecules
(Elsevier, 2013)
Coordinated interaction among cells is critical to develop the extremely complex and dynamic tasks performed by the central nervous system (CNS). Cell synchronization is in part mediated by connexins and pannexins; two ...
Gap junction channels and hemichannels in the CNS: regulation by signaling molecules
(Elsevier, 2013)
Coordinated interaction among cells is critical to develop the extremely complex and dynamic tasks performed by the central nervous system (CNS). Cell synchronization is in part mediated by connexins and pannexins; two ...
Pannexin channel and connexin hemichannel expression in vascular function and inflammation
(2017)
Abstract
Control of blood flow distribution and tissue homeostasis depend on the tight regulation of and coordination between the microvascular network and circulating blood cells. Channels formed by connexins ...
Pannexin channel and connexin hemichannel expression in vascular function and inflammation
(2017)
Control of blood flow distribution and tissue homeostasis depend on the tight regulation of and coordination between the microvascular network and circulating blood cells. Channels formed by connexins or pannexins that ...
Trypanosoma cruzi Infection Induces Pannexin-1 Channel Opening in Cardiac Myocytes
(2018)
Trypanosoma cruzi, the etiological agent of Chagas diseases, invades the cardiac tissue causing acute myocarditis and heart electrical disturbances. In T. cruzi invasion, the parasite induces [Ca2+](i) transients in the ...