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Genetic ablation of pannexin1 counteracts liver fibrosis in a chemical, but not in a surgical mouse model
(2018-08-01)
Liver fibrosis is the final common pathway for almost all causes of chronic liver injury. This chronic disease is characterized by excessive deposition of extracellular matrix components mainly due to transdifferentiation ...
Connexins and Pannexins in Bone and Skeletal Muscle
(2017)
Purpose of review To discuss current knowledge on the role of connexins and pannexins in the musculoskeletal system. Recent findings Connexins and pannexins are crucial for the development and maintenance of both bone and ...
Beneficial and Detrimental Remodeling of Glial Connexin and Pannexin Functions in Rodent Models of Nervous System Diseases
(Frontiers Media S.A., 2019-11)
A variety of glial cell functions are supported by connexin and pannexin proteins. These functions include the modulation of synaptic gain, the control of excitability through regulation of the ion and neurotransmitter ...
Pannexin 1: A novel participant in neuropathic pain signaling in the rat spinal cord
(Elsevier B.V., 2014)
© 2014 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.Pannexin 1 (panx1) is a large-pore membrane channel expressed in many tissues of mammals, including neurons and glial ...
Connexin and pannexin (hemi) channels in the liver
(Frontiers Media S.A.Lausanne, 2014-01)
The liver was among the first organs in which connexin proteins have been identified. Hepatocytes harbor connexin32 and connexin26, while non-parenchymal liver cells typically express connexin43. Connexins give rise to ...
Connexin hemichannels and pannexin channels contributes to the intracellular Ca2+ signal activated by PAF in endothelial cells of mesenteric post-capillary venules
(2016)
Endothelial cells form a permeability barrier to macromolecules that can be modulated in post-capillary venules through the activation of Ca2+-dependent signaling pathways by pro-inflammatory agents, such as platelet-activating ...