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Characterization of the regenerated Insulin-producing cells following pancreatic β-cell destruction in zebrafish
(2021)
Restoring damaged β-cells in diabetic patients by harnessing the plasticity of other
pancreatic cells raises the questions of the efficiency of the process and of the
functionality of the new Insulin-expressing cells. ...
3,4-dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, protects against pancreatic β-cells dysfunction induced by high cholesterol
(Academic Press Inc., 2015)
© 2015 Elsevier Inc. Cholesterol plays an important role in inducing pancreatic β-cell dysfunction, characterized by an impaired insulin secretory response to glucose, representing a hallmark of the transition from ...
Reduced pancreatic β-cell mass is associated with decreased FoxO1 and Erk1/2 protein phosphorylation in low-protein malnourished rats
(Associação Brasileira de Divulgação Científica (ABRADIC), 2009-10-01)
A low-protein diet leads to functional and structural pancreatic islet alterations, including islet hypotrophy. Insulin-signaling pathways are involved in several adaptive responses by pancreatic islets. We determined the ...
Reduced pancreatic β-cell mass is associated with decreased FoxO1 and Erk1/2 protein phosphorylation in low-protein malnourished rats
(Associação Brasileira de Divulgação Científica (ABRADIC), 2009-10-01)
A low-protein diet leads to functional and structural pancreatic islet alterations, including islet hypotrophy. Insulin-signaling pathways are involved in several adaptive responses by pancreatic islets. We determined the ...
Tetracaine stimulates insulin secretion through the mobilization of Ca2+ from thapsigargin- and IP3-insensitive Ca2+ reservoir in pancreatic β-cells
(2000-01-01)
The effect of tetracaine on 45Ca efflux, cytoplasmic Ca2+ concentration [Ca2+](i), and insulin secretion in isolated pancreatic islets and β-cells was studied. In the absence of external Ca2+, tetracaine (0.1-2.0 mM) ...
Reduced pancreatic β-cell mass is associated with decreased FoxO1 and Erk1/2 protein phosphorylation in low-protein malnourished rats
(Associação Brasileira de Divulgação Científica (ABRADIC), 2014)