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RSK activation via ERK modulates human colon cancer cells response to PTHrP
(BioScientifica, 2017-07)
Parathyroid hormone-related peptide (PTHrP) is associated with several human cancers such as colon carcinoma. This disease is a complex multistep process that involves enhanced cell cycle progression and migration. Recently ...
Role of PTHrP in human intestinal Caco-2 cell response to oxidative stress
(Elsevier, 2013-07)
We have previously demonstrated that parathyroid hormone (PTH) induces apoptosis in human colon adenocarcinoma Caco-2 cells but the effects of its tumoral analog PTH-related peptide (PTHrP) in this cell line are still ...
Role of SPARC in the epithelial-mesenchymal transition induced by PTHrP in human colon cancer cells
(Elsevier Ireland, 2021-06)
Parathyroid hormone-related peptide (PTHrP) exerts its effects on cells derived from colorectal cancer (CRC) and tumor microenvironment and is involved in processes requiring the epithelial-mesenchymal transition (EMT). ...
PTHrP treatment of colon cancer cells promotes tumor associated-angiogenesis by the effect of VEGF
(Elsevier Ireland, 2019-03)
We showed that Parathyroid Hormone-related Peptide (PTHrP) induces proliferation, migration, survival and chemoresistance via MAPKs and PI3K/AKT pathways in colorectal cancer (CRC) cells. The objective of this study was ...
Potential therapeutic targets for growth arrest of colorectal cancer cells exposed to PTHrP
(Elsevier Ireland, 2018-12-15)
Although PTHrP is implicated in several cancers, its role in chemoresistance is not fully elucidated. We found that in CRC cells, PTHrP exerts proliferative and protective effects and induces cell migration. The aim of ...
Molecular Mechanisms Associated With PTHrP-Induced Proliferation of Colon Cancer Cells
(Wiley, 2014-12)
Parathyroid Hormone-related Protein (PTHrP) is normally produced in many tissues and is recognized for its endocrine, paracrine, autocrine and intracrine modes of action. PTHrP is also implicated in different types of ...
Expression of parathyroid hormone related protein (PTHRP) in ameloblastomas
(2018)
Background: Presence of parathyroid hormone related protein (PTHrP) might suggest that ameloblastomas recapitulate features of the enamel epithelium and induce bone resorption, which would facilitate their growth and local ...
Mecanismos de acción del análogo tumoral de la hormona paratiroidea (PTHrP) en células de cáncer de colon humano
(2018-01-01)
La hormona paratiroidea (PTH) es un importante mediador de la remodelación ósea y actúa junto al calcitriol (1α,25(OH)2vitamina D3), como regulador esencial de la homeostasis del calcio y fósforo. El péptido relacionado ...
Association Between Calcium Intake, Parathormone Levels and Blood Pressure during Pregnancy.
(2011-12-19)
Purpose: To evaluate the association between calcium intake from diet, calciotropic hormones (PTH, PTH-rp), vasoactive
regulators (endothelin, nitric oxide) and blood pressure levels during pregnancy, birth and ...