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Alkane Chain-extended Pterin Through a Pendent Carboxylic Acid Acts as Triple Functioning Fluorophore, 1O2 Sensitizer and Membrane Binder
(Wiley Blackwell Publishing, Inc, 2019-03)
In order to develop a new long alkane chain pterin that leaves the pterin core largely unperturbed, we synthesized and photochemically characterized decyl pterin‐6‐carboxyl ester (CapC) that preserves the pterin amide ...
Kinetic Control in the Regioselective Alkylation of Pterin Sensitizers: A Synthetic, Photochemical, and Theoretical Study
(Wiley Blackwell Publishing, Inc, 2018-09)
Alkylation patterns and excited-state properties of pterins were examined both experimentally and theoretically. 2D NMR spectroscopy was used to characterize the pterin derivatives, revealing undoubtedly that the decyl ...
Photosensitization of peptides and proteins by pterin derivatives
(Walter de Gruyter GmbH, 2017-12)
Proteins are one of the preferential targets of the photosensitized damaging effects of ultraviolet (UV) radiation on biological system. Pterins belong to a family of heterocyclic compounds, which are widespread in living ...
Photo-Oxidation of Unilamellar Vesicles by a Lipophilic Pterin: Deciphering Biomembrane Photodamage
(American Chemical Society, 2018-12)
Pterins are natural products that can photosensitize the oxidation of DNA, proteins, and phospholipids. Recently, a new series of decyl-chain (i.e., lipophilic) pterins were synthesized and their photophysical properties ...
Thymidine radical formation via one-electron transfer oxidation photoinduced by pterin: Mechanism and products characterization
(Elsevier Science Inc, 2016-05)
UV-A radiation (320?400 nm), recognized as a class I carcinogen, induces damage to the DNA molecule and its components through different mechanisms. Pterin derivatives are involved in various biological functions, including ...