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Inactivation of tumor suppressor gene pten in early and advanced gallbladder cancer
(Biomed Central Ltd., 2015)
BACKGROUND:
PTEN is a tumor suppressor gene that regulates the PTEN/PI3k/AKT/mTOR pathway, which is frequently altered in human cancers including gallbladder cancer (GBC). To determine the frequency of PTEN expression in ...
Inactivation of tumor suppressor gene pten in early and advanced gallbladder cancer
(Biomed Central Ltd., 2015)
BACKGROUND:
PTEN is a tumor suppressor gene that regulates the PTEN/PI3k/AKT/mTOR pathway, which is frequently altered in human cancers including gallbladder cancer (GBC). To determine the frequency of PTEN expression in ...
Genetic and epi-genetic alterations of the PTEN gene : key in the relationship between type 2 diabetes and cancer
(Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Secretaria de Investigación y Posgrado, 2021-10-15)
Cancer pathogenesis has been associated with genetic and epigenetic alterations that may lead to the inactivation or decrease of tumor-suppressor genes, such as the PTEN gene. In particular, alterations in the PI3K/PTEN ...
Expressão do gene pten: avaliação imuno-histoquímica, sequenciamento genético e associação com p53, Ki-67 e CD31 em pacientes com carcinoma do colo do útero
(Universidade Federal de Minas GeraisUFMG, 2012-07-20)
Single nucleotide polymorphism in PTEN-Long gene : a risk factor in chronic myeloid leukemia
(Elsevier, 2019-04-30)
The BCR-ABL1 oncogene is associated with chronic myeloid leukemia (CML) pathogenesis, but the molecular mechanisms that initiate leukemogenesis are still unclear. Cancer pathogenesis has been associated with genetic ...
Alterations in PTEN, MDM2, TP53 and AR protein and gene expression are associated with canine prostate carcinogenesis
(2016-06-01)
The PTEN, AR, MDM2 and p53 protein network plays a central role in the development of many human cancers, thus eliciting the development of targeted cancer therapeutics. Dogs spontaneously develop tumours, and they are ...
Expression of LYN and PTEN genes in chronic myeloid leukemia and their importance in therapeutic strategy
(Elsevier Inc, 2013-10)
Tyrosine kinase inhibitors (TKIs), imatinib, nilotinib and dasatinib, are the current treatment of chronic myeloid leukemia (CML). BCR-ABL1 point mutations are the principal cause of resistance to treatment; however other ...
Análise da expressão da proteína PTEN em carcinoma papilar de tireoide
(Universidade Federal de Minas GeraisUFMG, 2012-08-03)
PTEN (phosphatase and tensin homologue) is a tumor suppressor gene, located on chromosome 10q23.3. The gene negatively regulates the PI3K/Akt pathway, stimulating apoptosis and blocking the cell proliferation and cell ...
Rol patogénico del gen supresor de tumores PTEN en cáncer ovárico asociado a endometriosis
(Sociedad Médica de Santiago, 2006)