In the adult hippocampus new neurons are generated in the dentate gyrus from neural progenitor cells. Adult-born neurons integrate into the hippocampal circuitry and contribute to hippocampal function. PSD95 is a major ...

Expression of Dlg4, which encodes the postsynaptic receptor clustering protein PSD95, is decreased in ageing and Alzheimer's disease. Bustos et al. engineer a zinc finger protein that modifies Dlg4 expression by changing ...

Expression of Dlg4, which encodes the postsynaptic receptor clustering protein PSD95, is decreased in ageing and Alzheimer's disease. Bustos et al. engineer a zinc finger protein that modifies Dlg4 expression by changing ...

El aprendizaje y memoria son procesos mentales fundamentales, sin dichos eventos, no seriamos capaces de generar más que reflejos y comportamientos estereotipados. La memoria es un cambio conductual causado por una experiencia ...

Alcohol hangover is defined as the combination of mental and physical symptoms experienced the day after a single episode of heavy drinking, starting when blood alcohol concentration approaches zero. We previously evidenced ...

The Dlg4 gene encodes for post-synaptic density protein 95 (PSD95), a major synaptic protein that clusters glutamate receptors and is critical for plasticity. PSD95 levels are diminished in ageing and neurodegenerative ...

During the formation of synapses, specific regions of pre- and postsynaptic cells associate to form a single functional transmission unit. In this process, synaptogenic factors are necessary to modulate pre- and postsynaptic ...

Reelin, an extracellular glycoprotein secreted in embryonic and adult brain, participates in neuronal migration and neuronal plasticity. Extensive evidence shows that reelin via activation of the ApoER2 and VLDLR receptors ...