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p75NTR and its ligand proNGF activate paracrine mechanisms etiological to the vascular, inflammatory, and neurodegenerative pathologies of diabetic retinopathy
(Society for Neuroscience, 2016-08)
In many diseases, expression and ligand-dependent activity of the p75NTR receptor can promote pericyte and vascular dysfunction, inflammation, glial activation, and neurodegeneration. Diabetic retinopathy (DR) is characterized ...
Antagonism of proNGF or its receptor p75NTR reverses remodelling and improves bladder function in a mouse model of diabetic voiding dysfunction
(Springer, 2020-09)
Although 80% of diabetic patients will suffer from voiding difficulties and urinary symptoms, defined as diabetic voiding dysfunction (DVD), therapeutic targets and treatment options are limited. We hypothesise that the ...
p75NTR antagonists attenuate photoreceptor cell loss in murine models of retinitis pigmentosa
(Nature Publishing Group, 2017-07)
ProNGF signaling through p75NTR has been associated with neurodegenerative disorders. Retinitis pigmentosa (RP) comprises a group of inherited retinal dystrophies that causes progressive photoreceptor cell degeneration and ...
Differential deregulation of NGF and BDNF neurotrophins in a transgenic rat model of Alzheimer's disease
(Academic Press Inc Elsevier Science, 2017-12)
Evidence from human neuropathological studies indicates that the levels of the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are compromised in Alzheimer's disease. However, the causes ...
Impact of the NGF Maturation and Degradation Pathway on the Cortical Cholinergic System Phenotype
(Society for Neuroscience, 2012-02)
Cortical cholinergic atrophy plays a significant role in the cognitive loss seen with aging and in Alzheimer's disease (AD), but the mechanisms leading to it remain unresolved. Nerve growth factor (NGF) is the neurotrophin ...
Maternal testosterone and placental function: Effect of electroacupuncture on placental expression of angiogenic markers and fetal growth
(Elsevier, 2016)
Women with polycystic ovary syndrome (PCOS) have elevated circulating androgens during pregnancy and are at an increased risk of adverse pregnancy outcomes. Here we tested the hypotheses that maternal androgen excess ...
Autonomic nervous system activation mediates the increase in whole-body glucose uptake in response to electroacupuncture
(FASEB, 2017)
© FASEB A single bout of low-frequency electroacupuncture (EA) causing muscle contractions increases wholebody glucose uptake in insulin-resistant rats.We explored the underlyingmechanism of this finding andwhether it can ...