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Opposing effects of quinacrine and chloroquine on the development of TA3 transplanted tumors in mice
(1995)
Both quinacrine and chloroquine had been used as antimalarial agents. Furthermore, antineoplastic and antiviral effects have been described for quinacrine, while chloroquine has been described to induce viral replication ...
Concomitant tumor resistance
(Elsevier Ireland, 2012-11)
Concomitant tumor resistance (CR) is a phenomenon in which a tumor-bearing host is resistant to the growth of secondary tumor implants. This phenomenon has been described in human and animal systems and it can be generated ...
Celecoxib decreases growth and angiogenesis and promotes apoptosis in a tumor cell line resistant to chemotherapy
(2014)
Background: During the last few years it has been shown in several laboratories that Celecoxib (Cx), a non-steroidal anti-inflammatory agent (NSAID) normally used for pain and arthritis, mediates antitumor and antiangiogenic ...
Paradoxical effects of cytokines in tumor iimune surveillance and tumor immune escape
(ELSEVIER SCI LTD, 2007)
The role of cytokines in modulating the formation of new tumors is mediated by their ability to regulate antigen-specific anti-tumor responses and by the activation of non-specific mechanisms, including those involved in ...
The acceleration of metastases after tumor removal and the paradoxical phenomenon of concomitant tumor resistance
(Noble Research, 2018-10)
Although surgical extirpation of tumors is usually clinically recommended, tumor removal may entail an undesired side effect: the risk of accelerating the growth of metastases. This effect may account for the relatively ...
Mind the gaps in tumor immunity: impact of connexin mediated intercellular connections
(Frontiers media SA, 2017)
Gap junctions (GJs)-mediated intercellular communications (GJICs) are connexin (Cx)-formed plasma membrane channels that allow for the passage of small molecules between adjacent cells, and are involved in several ...
Prognostic value of vascular endothelial growth factor and hypoxia-inducible factor 1α in canine malignant mammary tumors
(2015-01-01)
Mammary tumors are the most common type of tumor in dogs, with approximately half of these tumors being malignant. Hypoxia, characterized by oxygen levels below normal, is a known adverse factor to cancer treatment. The ...
Embryonal mass and hormone-associated effects of pregnancy inducing a differential growth of four murine tumors
(Cognizant Communication Corp, 2002-01)
A differential effect of pregnancy on the growth of subcutaneous implants of four murine tumors has been observed. Two tumors lacking receptors for progesterone and estrogen [methylcholanthrene-induced fibrosarcoma (MC-C) ...