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MRSA infections: from classical treatment to suicide drugs
(Bentham Science Publishers, 2014-02)
Infections caused by the methicillin-resistant Staphylococcus aureus (MRSA) are today a major burden in nosocomial disease control. The global trend shows an alarming increase of MRSA infections as well as multi-drug ...
Heparinas - Momento atual
(2008-11-01)
Synthesis, ex Vivo and in Vitro Hydrolysis Study of an Indoline Derivative Designed as an Anti-Inflammatory with Reduced Gastric Ulceration Properties
(Molecular Diversity Preservation International-mdpi, 2009-09-01)
The compound 1-(2,6-dichlorophenyl)indolin-2-one (1), planned as a pro-drug of diclofenac (2), was easily synthesized in 94% yield by an intramolecular reaction in the presence of coupling agent (i.e., EDC). Compound 1 ...
Synthesis, ex Vivo and in Vitro Hydrolysis Study of an Indoline Derivative Designed as an Anti-Inflammatory with Reduced Gastric Ulceration Properties
(Molecular Diversity Preservation International-mdpi, 2009-09-01)
The compound 1-(2,6-dichlorophenyl)indolin-2-one (1), planned as a pro-drug of diclofenac (2), was easily synthesized in 94% yield by an intramolecular reaction in the presence of coupling agent (i.e., EDC). Compound 1 ...
Bioavailability of phenolic compounds: a major challenge for drug development?
(Fundação Oswaldo Cruz. Farmanguinhos. Núcleo de Gestão em Biodiversidade e Saúde., 2017)
Prodrugs available on the Brazilian pharmaceutical market and their corresponding bioactivation pathways
(Universidade de São Paulo, Faculdade de Ciências Farmacêuticas, 2010)
The aim of this paper was to emphasize the importance of prodrug design to therapy, by examining examples available on the Brazilian pharmaceutical market. The principles of prodrug design are briefly discussed herein. ...
Heparinas - Momento atual
(2008-11-01)