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The axoneme: the propulsive engine of spermatozoa and cilia and associated ciliopathies leading to infertility
(Springer, 2016-02)
This review article provides a critical analysis of the structure and molecular mechanisms of the microtubule axoneme of cilia and sperm flagella and their associated elements required for male fertility. A broad range of ...
Neuron’s little helper: the role of primary cilia in neurogenesis
(TaylorFrancis, 2016)
The generation of new neurons involves a great variety of cell-extrinsic and cell-intrinsic signals. The primary cilium, long regarded as an “evolutionary vestige,” has emerged as an essential signaling hub in many cells, ...
Kartagener syndrome
(British Inst RadiologyLondonInglaterra, 2006)
Vasopressin receptor-mediated functional signaling pathway in primary cilia of renal epithelial cells
(American Physiological Society, 2009-01)
The primary cilium of renal epithelial cells is a nonmotile sensory organelle, implicated in mechanosensory transduction signals. Recent studies from our laboratory indicate that renal epithelial primary cilia display ...
Fibroblast Primary Cilia Are Required for Cardiac Fibrosis
(NLM (Medline), 2019)
BACKGROUND: The primary cilium is a singular cellular structure that extends from the surface of many cell types and plays crucial roles in vertebrate development, including that of the heart. Whereas ciliated cells have ...
Sonic Hedgehog Stimulates Proliferation of Human Periodontal Ligament Stem Cells
(SAGE PUBLICATIONS INC, 2011)
Regulation of cell renewal in the periodontium is a critical cell function that has not been clarified. Sonic hedgehog (Shh) is a secreted signaling molecule that plays a key role during development and adult tissue ...
Characterization of primary cilia during the differentiation of retinal ganglion cells in the zebrafish
(BioMed Central Ltd., 2016)
Background: Retinal ganglion cell (RGC) differentiation in vivo is a highly stereotyped process, likely resulting from the interaction of cell type-specific transcription factors and tissue-derived signaling factors. The ...
Methods for studying primary cilia in heart tissue after ischemia-reperfusion injury
(Academic Press Inc., 2023-01)
Cardiovascular diseases are the leading cause of death and disability worldwide. After heart injury triggered by myocardial ischemia or myocardial infarction, extensive zones of tissue are damaged and some of the tissue ...