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Effects of microinjections of apomorphine and haloperidol into the inferior colliculus on prepulse inhibition of the acoustic startle reflex in rat
(Elsevier B.V., 2012-02-10)
Prepulse inhibition (PPI) is the reduction in the startle response caused by a low intensity non-startling stimulus (prepulse) which is presented shortly before the startle stimulus and is an operational measure of ...
Nitric oxide synthase inhibitors improve prepulse inhibition responses of Wistar rats
(ELSEVIER SCIENCE BV, 2011)
Introduction: Cognitive and attentional deficits in schizophrenia include impairment of the sensorimotor filter as measured by prepulse inhibition (PPI). In this way, the study of animals that naturally present low PPI ...
A fast cholinergic modulation of the primary acoustic startle circuit in rats
(2013-06-04)
Cochlear root neurons (CRNs) are the first brainstem neurons which initiate and participate in the full expression of the acoustic startle reflex. Although it has been suggested that a cholinergic pathway from the ventral ...
A computational model for the modulation of the prepulseinhibition of the acoustic startle reflex
(Springer, 2012)
The acoustic startle reflex (ASR), a defensiveresponse, is a contraction of the skeletal and facial musclesin response to an abrupt, intense (>80 db) auditory stimu-lus, which has been extensively studied in rats and ...
Prepulse inhibition predicts working memory performance while startle habituation predicts spatial reference memory retention in C57BL/6 mice
(Elsevier Science, 2013-01)
Prepulse inhibition (PPI) of the acoustic startle reflex refers to the attenuation of the startle response to an intense pulse stimulus when it is shortly preceded by a weak non-startling prepulse stimulus. It is a ...
Baseline prepulse inhibition expression predicts the propensity of developing sensitization to the motor stimulant effects of amphetamine in C57BL/6 mice
(Springer, 2013-02)
Rationale The startle reflex to a sudden intense acoustic pulse stimulus is attenuated if the pulse is shortly preceded by a weak prepulse stimulus. This represents a form of sensory gating, known as prepulse inhibition ...
A fast cholinergic modulation of the primary acoustic startle circuit in rats
(2013-06-04)
Cochlear root neurons (CRNs) are the first brainstem neurons which initiate and participate in the full expression of the acoustic startle reflex. Although it has been suggested that a cholinergic pathway from the ventral ...
Nitric oxide modulation of methylphenidate-induced disruption of prepulse inhibition in Swiss mice
(ELSEVIER SCIENCE BV, 2009)
Drugs that facilitate dopaminergic neurotransmission induce cognitive and attentional deficits which include inability to filter sensory input measured by prepulse inhibition (PPI) Methylphenidate, an amphetamine analog ...
Spontaneously Hypertensive Rats (SHR) present deficits in prepulse inhibition of startle specifically reverted by clozapine
(Elsevier B.V., 2011-08-15)
Deficits in an operational measure of sensorimotor gating - the prepulse inhibition of startle (PPI) - are presented in psychiatric disorders such as schizophrenia, bipolar disorder, and attention deficit/hyperactivity ...
The 5-HT5A receptor regulates excitability in the auditory startle circuit: functional implications for sensorimotor gating
(Society for Neuroscience, 2013-06)
Here we applied behavioral testing, pharmacology, and in vivo electrophysiology to determine the function of the serotonin 5-HT5A receptor in goldfish startle plasticity and sensorimotor gating. In an initial series of ...