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White matter fiber density abnormalities in cognitively normal adults at risk for late-onset Alzheimer's disease
(Pergamon-Elsevier Science Ltd, 2020-03)
Tau accumulation affecting white matter tracts is an early neuropathological feature of late-onset Alzheimer's disease (LOAD). There is a need to ascertain methods for the detection of early LOAD features to help with ...
White matter fiber density abnormalities in cognitively normal adults at risk for late-onset Alzheimer's disease
(Pergamon-Elsevier Science Ltd, 2020-03)
Tau accumulation affecting white matter tracts is an early neuropathological feature of late-onset Alzheimer's disease (LOAD). There is a need to ascertain methods for the detection of early LOAD features to help with ...
Executive functioning in cognitively normal middle-aged offspring of late-onset Alzheimer's disease patients
(Pergamon-Elsevier Science Ltd, 2019-05)
Episodic memory deficits are traditionally seen as the hallmark cognitive impairment during the prodromal continuum of late-onset Alzheimer's disease (LOAD). Previous studies identified early brain alterations in regions ...
Comparing cortical signatures of atrophy between late-onset and autosomal dominant Alzheimer disease
(Elsevier, 2020-01)
Defining a signature of cortical regions of interest preferentially affected by Alzheimer disease (AD) pathology may offer improved sensitivity to early AD compared to hippocampal volume or mesial temporal lobe alone. Since ...
Executive functioning in cognitively normal middle-aged offspring of late-onset Alzheimer's disease patients
(Elsevier, 2019)
Abstract: Episodic memory deficits are traditionally seen as the hallmark cognitive impairment during the prodromal continuum of late-onset Alzheimer's disease (LOAD). Previous studies identified early brain alterations ...
Brain structural and amyloid correlates of recovery from semantic interference in cognitively normal individuals with or without family history of late-onset alzheimer’s disease
(American Psychiatric Publishing, Inc, 2019-01)
Failure to recover from proactive semantic interference (frPSI) has been shown to be more sensitive than traditional cognitive measures in different populations with preclinical Alzheimer’s disease. The authors sought to ...
Brain structural and amyloid correlates of recovery from semantic interference in cognitively normal individuals with or without gamily history of late-onset Alzheimer's disease
(American Psychiatric Association, 2019)
Abstract: Failure to recover from proactive semantic interference (frPSI) has been shown to be more sensitive than traditional cognitive measures in different populations with preclinical Alzheimer’s disease. The authors ...
Cortical thickness, brain metabolic activity, and in vivo amyloid deposition in asymptomatic, middle-aged offspring of patients with late-onset Alzheimer's disease
(Pergamon-Elsevier Science Ltd, 2018-12)
The natural history of preclinical late-onset Alzheimer's disease (LOAD) remains obscure and has received less attention than that of early-onset AD (EOAD), in spite of accounting for more than 99% of cases of AD. With the ...
The Impact of Apolipoprotein E Allelic Variants on Alzheimer´s Disease
(Springer Nature Switzerland AG, 2021)
Alzheimer disease (AD) is a genetically and clinically complex neurodegenerative disease, often with decades-long preclinical and prodromal stages. In older adults, it is the most frequent form of dementia. Apolipoprotein ...
Cortical thickness, brain metabolic activity, and in vivo amyloid deposition in asymptomatic, middle-aged offspring of patients with late-onset Alzheimer's disease
(Elsevier, 2018)
Abstract: The natural history of preclinical late-onset Alzheimer's disease (LOAD) remains obscure and has received less attention than that of early-onset AD (EOAD), in spite of accounting for more than 99% of cases of ...