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Biological and clinical impact of imbalanced progesterone receptor isoform ratios in breast cancer
(BioScientifica, 2018-12)
There is a consensus that progestins and thus their cognate receptor molecules, the progesterone receptors (PRs), are essential in the development of the adult mammary gland and regulators of proliferation and lactation. ...
Role for mifepristone in breast cancer
(Nova Science Publisher's, 2014)
Mifepristone (MFP) is an antiprogestin that has shown some beneficial effects in breast cancer clinical trials. Interestingly, progestins such as medroxyprogesterone acetate (MPA) have also been used as second or third ...
Isoform specificity of progesterone receptor antibodies
(Wiley Online Library, 2017-10)
Progesterone receptors (PR) are prognostic and predictive biomarkers in hormone-dependent cancers. Twomain PR isoforms have been described, PRB and PRA, that differ only in that PRB has 164 extra N-terminalamino acids. It ...
The effectiveness of nano chemotherapeutic particles combined with mifepristone depends on the PR isoform ratio in preclinical models of breast cancer
(Impact Journals, 2014-04-27)
There is clinical and experimental evidence suggesting that antiprogestins might be used for the treatment of selected breast cancer patients. Our aim was to evaluate the effect of albumin-bound paclitaxel (Nab-paclitaxel) ...
Progesterone receptor isoform ratio dictates antiprogestin/progestin effects on breast cancer growth and metastases: A role for NDRG1
(John Wiley & Sons Inc., 2021)
Progesterone receptors (PRs) ligands are being tested in luminal breast cancer. There are mainly two PR isoforms, PRA and PRB, and their ratio (PRA/PRB) may be predictive of antiprogestin response. Our aim was to investigate: ...
Progesterone receptor isoform ratio: a breast cancer prognostic and predictive factor for antiprogestin responsiveness
(Oxford Univ Press Inc, 2017-07)
Compelling evidence shows that progestins regulate breast cancer growth. Using preclinical models, we demonstrated that antiprogestins are inhibitory when the level of progesterone receptor isoform A (PR-A) is higher than ...
Gene expression profile and cancer-associated pathways linked to progesterone receptor isoform a (PRA) predominance in transgenic mouse mammary glands
(2018-06-25)
Abstract
Background
Progesterone receptor (PR) is expressed from a single gene as two isoforms, PRA and PRB. In normal breast human tissue, PRA and PRB are expressed in equimolar ...
Hormone receptors in breast cancer: more than estrogen receptorsReceptores hormonales en cáncer de mama: receptores de estrógenos y algo más
(Medicina Buenos Aires, 2019-12)
Seventy per cent of breast cancers are luminal carcinomas that express alpha estrogen receptors (ER). For several decades, its expression has been used as a therapeutic target in patients with breast cancer. These therapies ...
Progestin and antiprogestin responsiveness in breast cancer is driven by the PRA/PRB ratio via AIB1 or SMRT recruitment to the CCND1 and MYC promoters
(John Wiley & Sons Inc, 2014-11-12)
There is emerging interest in understanding the role of progesterone receptors (PRs) in breast cancer. The aim of this study was to investigate the proliferative effect of progestins and antiprogestins depending on the ...