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Molecular properties of fatty acids related to PPAR binding and metabolic diseases
(SpringerBasel, 2013-07)
Peroxisome proliferator-activated receptor (PPAR) is a class of nuclear receptors responsible for the transcription of genes that regulate the metabolism of carbohydrates and lipids. The main endogenous ligands of PPARs ...
Planejamento, síntese e avaliação farmacológica de novos compostos híbridos derivados de resveratrol e bezafibrato úteis ao tratamento da dislipidemia
(Universidade Estadual Paulista (Unesp), 2017-12-20)
A dislipidemia causada por hipertrigliceridemia e baixo HDL-C é um marcador de risco para a progressão da aterosclerose e doenças cardiovasculares. Os receptores PPARs são fatores de transcrição que controlam a expressão ...
Fenofibrate Decreases Ethanol-Induced Neuroinflammation and Oxidative Stress and Reduces Alcohol Relapse in Rats by a PPAR-α-Dependent Mechanism
(Multidisciplinary Digital Publishing Institute (MDPI), 2024)
Agonistas de los PPAR como reguladores de anomalías fetales inducidas por la diabetes maternaPPAR agonists as regulators of fetal anomalies induced by maternal diabetes
(Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires, 2016)
Bioactive Compounds as PPARs Ligands: Potential Health Effects
(2019-03)
Peroxisome proliferator-activated receptors (PPARs) are transcription factors whose isoforms (α, β/δ, and γ) have key and complementary roles in relation to energy metabolism, glucose and lipid homeostasis, regulation of ...
N-3 PUFA supplementation triggers PPAR-α activation and PPAR-α/NF-κB interaction: Anti-inflammatory implications in liver ischemia-reperfusion injury
(2011)
Dietary supplementation with the n-3 polyunsaturated fatty acids (n-3 PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) to rats preconditions the liver against ischemia-reperfusion (IR) injury, with reduction ...
Rosa mosqueta oil prevents oxidative stress and inflammation through the upregulation of PPAR-α and NRF2 in C57BL/6J mice fed a high-fat diet
(American Society for Nutrition, 2017)
© 2017 American Society for Nutrition. Background: Rosa mosqueta (RM) oil is characterized by high concentrations of antioxidants and α-linolenic acid (ALA; 18:3n-3). We have previously demonstrated in male C57BL/6J mice ...
Avaliação do extrato do fungo caripia montagnei e de agonistas de PPAR - α no processo inflamatório
(Universidade Federal do Rio Grande do NorteBRUFRNPrograma de Pós-Graduação em BioquímicaBioquímica; Biologia Molecular, 2008-06-27)
The mushrooms have been object of intense research in view of its potential raising of application in different sectors of the pharmacology and alimentary industry. Among diverse bioactive composites of polyssacharides ...